Format

Send to:

Choose Destination

H1FX H1 histone family member X [ Homo sapiens (human) ]

Gene ID: 8971, updated on 15-Jun-2019

Summary

Official Symbol
H1FXprovided by HGNC
Official Full Name
H1 histone family member Xprovided by HGNC
Primary source
HGNC:HGNC:4722
See related
Ensembl:ENSG00000184897 MIM:602785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1X; H1.10
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Orthologs

Genomic context

See H1FX in Genome Data Viewer
Location:
3q21.3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (129314771..129316277, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129033614..129035120, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene coatomer protein complex subunit gamma 1 Neighboring gene microRNA 6826 Neighboring gene 5-hydroxymethylcytosine binding, ES cell specific Neighboring gene H1FX antisense RNA 1 Neighboring gene nucleoporin 210 pseudogene 3 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 3

Genomic regions, transcripts, and products

Bibliography

Related articles in PubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8350, MGC15959

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
nucleosome positioning IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006026.4NP_006017.1  histone H1x

    See identical proteins and their annotated locations for NP_006017.1

    Status: REVIEWED

    Source sequence(s)
    AC137695, BC000426, BC010435
    Consensus CDS
    CCDS3057.1
    UniProtKB/Swiss-Prot
    Q92522
    Related
    ENSP00000329662.4, ENST00000333762.6
    Conserved Domains (1) summary
    cd00073
    Location:47120
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    129314771..129316286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center