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KYNU kynureninase [ Homo sapiens (human) ]

Gene ID: 8942, updated on 11-Sep-2019

Summary

Official Symbol
KYNUprovided by HGNC
Official Full Name
kynureninaseprovided by HGNC
Primary source
HGNC:HGNC:6469
See related
Ensembl:ENSG00000115919 MIM:605197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KYNUU; VCRL2
Summary
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Expression
Broad expression in liver (RPKM 2.5), urinary bladder (RPKM 1.8) and 14 other tissues See more
Orthologs

Genomic context

See KYNU in Genome Data Viewer
Location:
2q22.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (142877664..143055833)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (143506497..143799885)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA polymerase I-specific transcription initiation factor RRN3-like Neighboring gene uncharacterized LOC105373652 Neighboring gene HNF1 motif-containing MPRA enhancer 151 Neighboring gene sideroflexin 4 pseudogene Neighboring gene stress induced phosphoprotein 1 pseudogene 1 Neighboring gene Rho GTPase activating protein 15 Neighboring gene MT-CYB pseudogene 11 Neighboring gene MT-ND6 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hydroxykynureninuria
MedGen: C0268474 OMIM: 236800 GeneReviews: Not available
Compare labs
VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 2
MedGen: C4540014 OMIM: 617661 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genome-wide association study of selenium concentrations.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of kynureninase (KYNU) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-hydroxykynureninase activity IDA
Inferred from Direct Assay
more info
PubMed 
kynureninase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kynureninase activity IDA
Inferred from Direct Assay
more info
PubMed 
kynureninase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
 
L-kynurenine catabolic process IEA
Inferred from Electronic Annotation
more info
 
NAD biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
anthranilate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anthranilate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
quinolinate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
response to vitamin B6 IMP
Inferred from Mutant Phenotype
more info
PubMed 
tryptophan catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
tryptophan catabolic process TAS
Traceable Author Statement
more info
 
tryptophan catabolic process to acetyl-CoA IEA
Inferred from Electronic Annotation
more info
 
tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
kynureninase
Names
L-kynurenine hydrolase
NP_001028170.1
NP_001186170.1
NP_003928.1
XP_011510404.1
XP_016860706.1
XP_024308976.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023254.1 RefSeqGene

    Range
    5001..169691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032998.2NP_001028170.1  kynureninase isoform b

    See identical proteins and their annotated locations for NP_001028170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and coding region compared to variant 3. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC013444, BC000879
    Consensus CDS
    CCDS33299.1
    UniProtKB/Swiss-Prot
    Q16719
    Related
    ENSP00000364928.2, ENST00000375773.6
    Conserved Domains (1) summary
    cl28159
    Location:30301
    Aminotran_5; Aminotransferase class-V
  2. NM_001199241.2NP_001186170.1  kynureninase isoform a

    See identical proteins and their annotated locations for NP_001186170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript variant. Variants 1 and 3 encode isoform a.
    Source sequence(s)
    AC013437, AK315343, AW290980
    Consensus CDS
    CCDS2183.1
    UniProtKB/Swiss-Prot
    Q16719
    Related
    ENSP00000386731.1, ENST00000409512.5
    Conserved Domains (1) summary
    TIGR01814
    Location:30459
    kynureninase; kynureninase
  3. NM_003937.3NP_003928.1  kynureninase isoform a

    See identical proteins and their annotated locations for NP_003928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5'UTR compared to variant 3.
    Source sequence(s)
    AC013437, AL548658, AW296221, U57721
    Consensus CDS
    CCDS2183.1
    UniProtKB/Swiss-Prot
    Q16719
    Related
    ENSP00000264170.4, ENST00000264170.9
    Conserved Domains (1) summary
    TIGR01814
    Location:30459
    kynureninase; kynureninase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    142877664..143055833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005217.1XP_016860706.1  kynureninase isoform X3

    UniProtKB/Swiss-Prot
    Q16719
    Conserved Domains (1) summary
    cl28159
    Location:30301
    Aminotran_5; Aminotransferase class-V
  2. XM_024453208.1XP_024308976.1  kynureninase isoform X1

    Conserved Domains (1) summary
    TIGR01814
    Location:30459
    kynureninase; kynureninase
  3. XM_011512102.2XP_011510404.1  kynureninase isoform X2

    See identical proteins and their annotated locations for XP_011510404.1

    Conserved Domains (1) summary
    cl18945
    Location:1329
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RNA

  1. XR_923058.1 RNA Sequence

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