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CDK5R2 cyclin dependent kinase 5 regulatory subunit 2 [ Homo sapiens (human) ]

Gene ID: 8941, updated on 13-Mar-2020

Summary

Official Symbol
CDK5R2provided by HGNC
Official Full Name
cyclin dependent kinase 5 regulatory subunit 2provided by HGNC
Primary source
HGNC:HGNC:1776
See related
Ensembl:ENSG00000171450 MIM:603764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P39; NCK5AI; p39nck5ai
Summary
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See CDK5R2 in Genome Data Viewer
Location:
2q35
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218959666..218962155)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219824350..219826877)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1494 Neighboring gene RNA, U6 small nuclear 642, pseudogene Neighboring gene keratin 8 pseudogene 30 Neighboring gene long intergenic non-protein coding RNA 608 Neighboring gene FEV transcription factor, ETS family member

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cyclin-dependent kinase 5, regulatory subunit 2, p39 (CDK5R2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclin-dependent protein serine/threonine kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclin-dependent protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
superior olivary nucleus maturation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein kinase 5 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 5 activator 2
Names
CDK5 activator 2
cyclin-dependent kinase 5 activator isoform p39i
neuronal CDK5 activator isoform
p39I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003936.5NP_003927.1  cyclin-dependent kinase 5 activator 2

    See identical proteins and their annotated locations for NP_003927.1

    Status: REVIEWED

    Source sequence(s)
    AC097468
    Consensus CDS
    CCDS2427.1
    UniProtKB/Swiss-Prot
    Q13319
    Related
    ENSP00000304250.4, ENST00000302625.6
    Conserved Domains (1) summary
    pfam03261
    Location:40326
    CDK5_activator; Cyclin-dependent kinase 5 activator protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218959666..218962155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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