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hdrA dihydrofolate reductase HdrA [ Haloferax volcanii DS2 ]

Gene ID: 8925483, updated on 7-May-2024

Summary

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Gene symbol
hdrA
Gene description
dihydrofolate reductase HdrA
Locus tag
HVO_RS10850
Gene type
protein coding
Organism
Haloferax volcanii DS2 (strain: DS2, type-material: type strain of Halobacterium volcanii)
Lineage
Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales; Haloferacaceae; Haloferax
Also known as
folA
Old locus tag
HVO_1279
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Genomic context

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Sequence:
NC_013967.1 (1166683..1167171)

NC_013967.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene MFS transporter Neighboring gene glycosyltransferase family 4 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_013967.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii. Pieper U, et al. Structure, 1998 Jan 15. PMID 9493269
  2. Dihydrofolate reductase of the extremely halophilic archaebacterium Halobacterium volcanii. The enzyme and its coding gene. Zusman T, et al. J Biol Chem, 1989 Nov 15. PMID 2509470
  3. The complete genome sequence of Haloferax volcanii DS2, a model archaeon. Hartman AL, et al. PLoS One, 2010 Mar 19. PMID 20333302, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
dihydrofolate reductase HdrA
WP_004043660.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_013967.1 Reference assembly

    Range
    1166683..1167171
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_004043660.1 dihydrofolate reductase HdrA [Haloferax volcanii]

    See identical proteins and their annotated locations for WP_004043660.1

    UniProtKB/Swiss-Prot
    D4GXA6, L9UT07, P15093
    UniProtKB/TrEMBL
    A0A8T5C6Q7
    Conserved Domains (1) summary
    cd00209
    Location:3 → 156
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15093.1

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