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GYG2 glycogenin 2 [ Homo sapiens (human) ]

Gene ID: 8908, updated on 11-Jun-2021

Summary

Official Symbol
GYG2provided by HGNC
Official Full Name
glycogenin 2provided by HGNC
Primary source
HGNC:HGNC:4700
See related
Ensembl:ENSG00000056998 MIM:300198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GN2; GN-2
Summary
This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
Expression
Biased expression in fat (RPKM 111.6) and liver (RPKM 4.8) See more
Orthologs
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Genomic context

See GYG2 in Genome Data Viewer
Location:
Xp22.33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (2828712..2882820)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (2746971..2800859)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CD99 molecule (Xg blood group) Neighboring gene Xg glycoprotein (Xg blood group) Neighboring gene ARSD antisense RNA 1 Neighboring gene arylsulfatase D Neighboring gene arylsulfatase L

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycogenin glucosyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
enables glycogenin glucosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glycogenin-2
Names
glycogenin glucosyltransferase
NP_001073324.1
NP_001171631.1
NP_001171632.1
NP_001171633.1
NP_003909.2
XP_011543902.1
XP_016885416.1
XP_016885417.1
XP_016885418.1
XP_016885419.1
XP_016885420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021257.1 RefSeqGene

    Range
    5001..58999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001079855.2NP_001073324.1  glycogenin-2 isoform a

    See identical proteins and their annotated locations for NP_001073324.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an in-frame exon in the CDS, as compared to variant 2. The resulting isoform (a) lacks an internal segment, as compared to isoform b.
    Source sequence(s)
    BC023152, CB410312, U94361, U94362
    Consensus CDS
    CCDS48074.1
    UniProtKB/Swiss-Prot
    O15488
    Related
    ENSP00000381786.3, ENST00000398806.8
    Conserved Domains (2) summary
    cd02537
    Location:6257
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:11275
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
  2. NM_001184702.2NP_001171631.1  glycogenin-2 isoform c

    See identical proteins and their annotated locations for NP_001171631.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and a 3 nt segment in the CDS, as compared to variant 2. The resulting isoform (c, also known as beta) lacks an internal segment in the N-terminal region and an amino acid Q in the C-terminal region, as compared to isoform b.
    Source sequence(s)
    AC005295, U94361, U94362, U94363
    UniProtKB/Swiss-Prot
    O15488
    Conserved Domains (2) summary
    cd02537
    Location:6257
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:11275
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
  3. NM_001184703.2NP_001171632.1  glycogenin-2 isoform d

    See identical proteins and their annotated locations for NP_001171632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two consecutive in-frame exons in the 3' CDS, as compared to variant 2. The resulting isoform (d) lacks an internal segment in the C-terminal region, as compared to isoform b.
    Source sequence(s)
    AC005295, DQ424901, U94361, U94362
    Consensus CDS
    CCDS55365.1
    UniProtKB/Swiss-Prot
    O15488
    UniProtKB/TrEMBL
    Q1ZYL7
    Related
    ENSP00000487294.1, ENST00000353656.10
    Conserved Domains (2) summary
    cd02537
    Location:37288
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:42306
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
  4. NM_001184704.2NP_001171633.1  glycogenin-2 isoform e

    See identical proteins and their annotated locations for NP_001171633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two consecutive exons in the 5' CDS, resulting in a downstream in-frame AUG start codon, and also lacks two consecutive in-frame exons in the 3' CDS, as compared to variant 2. The resulting isoform (e) has a shorter N-terminus and lacks an internal segment in the C-terminal region, as compared to isoform b.
    Source sequence(s)
    AC005295, AK098046, U94361
    UniProtKB/Swiss-Prot
    O15488
    UniProtKB/TrEMBL
    B3KUV6
    Related
    ENST00000381161.5
    Conserved Domains (1) summary
    cl11394
    Location:1102
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  5. NM_003918.3NP_003909.2  glycogenin-2 isoform b

    See identical proteins and their annotated locations for NP_003909.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (b, also known as alpha).
    Source sequence(s)
    BC023152, CB410312, U94361, U94362
    Consensus CDS
    CCDS14121.1
    UniProtKB/Swiss-Prot
    O15488
    Related
    ENSP00000370555.3, ENST00000381163.7
    Conserved Domains (2) summary
    cd02537
    Location:37288
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:42306
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    2828712..2882820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029929.1XP_016885418.1  glycogenin-2 isoform X2

    Conserved Domains (2) summary
    cd02537
    Location:37288
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:42306
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
  2. XM_017029930.1XP_016885419.1  glycogenin-2 isoform X4

    Conserved Domains (2) summary
    cd02537
    Location:6257
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:11275
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
  3. XM_017029928.1XP_016885417.1  glycogenin-2 isoform X1

    UniProtKB/Swiss-Prot
    O15488
    Conserved Domains (2) summary
    cd02537
    Location:37288
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:42306
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
  4. XM_017029927.1XP_016885416.1  glycogenin-2 isoform X1

    UniProtKB/Swiss-Prot
    O15488
    Conserved Domains (2) summary
    cd02537
    Location:37288
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:42306
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
  5. XM_011545600.2XP_011543902.1  glycogenin-2 isoform X3

    See identical proteins and their annotated locations for XP_011543902.1

    UniProtKB/Swiss-Prot
    O15488
    Conserved Domains (2) summary
    cd02537
    Location:6257
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:11275
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
  6. XM_017029931.1XP_016885420.1  glycogenin-2 isoform X4

    Conserved Domains (2) summary
    cd02537
    Location:6257
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:11275
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
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