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KRIT1 KRIT1, ankyrin repeat containing [ Homo sapiens (human) ]

Gene ID: 889, updated on 18-Nov-2018

Summary

Official Symbol
KRIT1provided by HGNC
Official Full Name
KRIT1, ankyrin repeat containingprovided by HGNC
Primary source
HGNC:HGNC:1573
See related
Ensembl:ENSG00000001631 Ensembl:ENSG00000285953 MIM:604214; Vega:OTTHUMG00000131187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAM; CCM1
Summary
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in testis (RPKM 10.9), thyroid (RPKM 10.0) and 25 other tissues See more
Orthologs

Genomic context

See KRIT1 in Genome Data Viewer
Location:
7q21.2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (92198969..92246100, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (91828283..91875414, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 9 Neighboring gene CYP51A1 antisense RNA 1 Neighboring gene cytochrome P450 family 51 subfamily A member 1 Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene microRNA 1285-1 Neighboring gene ankyrin repeat and IBR domain containing 1 Neighboring gene transmembrane BAX inhibitor motif containing 7, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase regulator activity TAS
Traceable Author Statement
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
krev interaction trapped protein 1
Names
ankyrin repeat-containing protein Krit1
cerebral cavernous malformations 1 protein
krev interaction trapped 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012964.1 RefSeqGene

    Range
    5001..52132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_650

mRNA and Protein(s)

  1. NM_001013406.2NP_001013424.1  krev interaction trapped protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001013424.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' exon, and lacks 2 exons in the 5' UTR and an in-frame exon in the coding region, as compared to variant 1. The encoded isoform 2 lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS34679.1
    UniProtKB/Swiss-Prot
    O00522
    Related
    ENSP00000378011.2, OTTHUMP00000208802, ENST00000394503.6
    Conserved Domains (5) summary
    smart00295
    Location:373592
    B41; Band 4.1 homologues
    cd13197
    Location:588687
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:306338
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:282363
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  2. NM_001350669.1NP_001337598.1  krev interaction trapped protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 5 and 7, encodes isoform 2.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS34679.1
    Conserved Domains (5) summary
    smart00295
    Location:373592
    B41; Band 4.1 homologues
    cd13197
    Location:588687
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:306338
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:282363
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  3. NM_001350670.1NP_001337599.1  krev interaction trapped protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform 2.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS34679.1
    Conserved Domains (5) summary
    smart00295
    Location:373592
    B41; Band 4.1 homologues
    cd13197
    Location:588687
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:306338
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:282363
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  4. NM_001350671.1NP_001337600.1  krev interaction trapped protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC000120
    Conserved Domains (4) summary
    smart00295
    Location:183402
    B41; Band 4.1 homologues
    cd00204
    Location:53173
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:398497
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:5380
    ANK; ANK repeat [structural motif]
  5. NM_001350672.1NP_001337601.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1-4 and 10-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  6. NM_001350673.1NP_001337602.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1-4, 9, and 11-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  7. NM_001350674.1NP_001337603.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1-4, 9, 10, and 12-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  8. NM_001350675.1NP_001337604.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1-4, 9-11, and 13-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  9. NM_001350676.1NP_001337605.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1-4, 9-12, and 14-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  10. NM_001350677.1NP_001337606.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 1-4, 9-13, and 15-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  11. NM_001350678.1NP_001337607.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 1-4, 9-14, and 16-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  12. NM_001350679.1NP_001337608.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 1-4, 9-15, and 17-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  13. NM_001350680.1NP_001337609.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variants 1-4 and 9-33, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  14. NM_001350681.1NP_001337610.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 1-4, 9-16, and 18-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  15. NM_001350682.1NP_001337611.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 1-4, 9-17, and 19-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  16. NM_001350683.1NP_001337612.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 1-4, 9-18, and 20-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  17. NM_001350684.1NP_001337613.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 1-4, 9-19, and 21-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  18. NM_001350685.1NP_001337614.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 1-4, 9-20, and 22-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  19. NM_001350686.1NP_001337615.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 1-4, 9-21, and 23-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  20. NM_001350687.1NP_001337616.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 1-4, 9-22, and 24-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  21. NM_001350688.1NP_001337617.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 1-4, 9-23, and 25-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  22. NM_001350689.1NP_001337618.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 1-4, 9-24, and 26-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  23. NM_001350690.1NP_001337619.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 1-4, 9-25, and 27-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  24. NM_001350691.1NP_001337620.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 1-4, 9-26, and 28-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  25. NM_001350692.1NP_001337621.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 1-4, 9-27, and 29-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  26. NM_001350693.1NP_001337622.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 1-4, 9-28, and 30-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  27. NM_001350694.1NP_001337623.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 1-4, 9-29, and 31-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  28. NM_001350695.1NP_001337624.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 1-4, 9-30, and 32-34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  29. NM_001350696.1NP_001337625.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 1-4, 9-31, 33, and 34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  30. NM_001350697.1NP_001337626.1  krev interaction trapped protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 1-4, 9-32, and 34, encodes isoform 1.
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  31. NM_004912.4NP_004903.2  krev interaction trapped protein 1 isoform 1

    See identical proteins and their annotated locations for NP_004903.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the 5' exon but has an alternate segment in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Related
    ENSP00000410909.2, OTTHUMP00000208804, ENST00000412043.6
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  32. NM_194454.2NP_919436.1  krev interaction trapped protein 1 isoform 1

    See identical proteins and their annotated locations for NP_919436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks 2 exons but has an alternate exon in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AC000120
    Consensus CDS
    CCDS5624.1
    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Related
    ENSP00000378013.2, OTTHUMP00000208803, ENST00000394505.6
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  33. NM_194455.1NP_919437.1  krev interaction trapped protein 1 isoform 1

    See identical proteins and their annotated locations for NP_919437.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has 2 alternate exons in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AF388384
    Consensus CDS
    CCDS5624.1
    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Related
    ENSP00000344668.2, OTTHUMP00000161833, ENST00000340022.6, OTTHUMT00000253910
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  34. NM_194456.1NP_919438.1  krev interaction trapped protein 1 isoform 1

    See identical proteins and their annotated locations for NP_919438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) includes 4 exons in the 5' UTR. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AF296765, AF388384, AJ294850
    Consensus CDS
    CCDS5624.1
    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Related
    ENSP00000378015.1, ENST00000394507.5
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    92198969..92246100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516654.3XP_011514956.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514956.1

    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  2. XM_011516651.3XP_011514953.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514953.1

    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  3. XM_005250666.4XP_005250723.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005250723.1

    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  4. XM_024446983.1XP_024302751.1  krev interaction trapped protein 1 isoform X1

    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  5. XM_006716162.4XP_006716225.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006716225.1

    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Related
    ENSP00000498010.1, ENST00000650585.1
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  6. XM_011516655.3XP_011514957.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514957.1

    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  7. XM_024446984.1XP_024302752.1  krev interaction trapped protein 1 isoform X3

    Conserved Domains (4) summary
    smart00295
    Location:142361
    B41; Band 4.1 homologues
    cd00204
    Location:12132
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:357456
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:1239
    ANK; ANK repeat [structural motif]
  8. XM_011516659.3XP_011514961.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514961.1

    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  9. XM_017012758.2XP_016868247.1  krev interaction trapped protein 1 isoform X2

    Conserved Domains (4) summary
    smart00295
    Location:183402
    B41; Band 4.1 homologues
    cd00204
    Location:53173
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:398497
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:5380
    ANK; ANK repeat [structural motif]
  10. XM_024446982.1XP_024302750.1  krev interaction trapped protein 1 isoform X1

    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  11. XM_011516660.3XP_011514962.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514962.1

    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
  12. XM_011516658.3XP_011514960.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011514960.1

    UniProtKB/Swiss-Prot
    O00522
    UniProtKB/TrEMBL
    A4D1F7
    Conserved Domains (5) summary
    smart00295
    Location:421640
    B41; Band 4.1 homologues
    cd00204
    Location:291411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291318
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:30198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
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