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PRPF4B pre-mRNA processing factor 4B [ Homo sapiens (human) ]

Gene ID: 8899, updated on 11-Sep-2019

Summary

Official Symbol
PRPF4Bprovided by HGNC
Official Full Name
pre-mRNA processing factor 4Bprovided by HGNC
Primary source
HGNC:HGNC:17346
See related
Ensembl:ENSG00000112739 MIM:602338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR4H; PRP4; PRP4H; PRP4K; dJ1013A10.1
Summary
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.5) and 25 other tissues See more
Orthologs

Genomic context

See PRPF4B in Genome Data Viewer
Location:
6p25.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (4021300..4064983)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (4021563..4065217)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 4 Neighboring gene glutaredoxin 3 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 2502 Neighboring gene family with sequence similarity 217 member A Neighboring gene chromosome 6 open reading frame 201 Neighboring gene enoyl-CoA delta isomerase 2 Neighboring gene uncharacterized LOC107986559 Neighboring gene ECI2 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, pre-mRNA processing factor 4 homolog B (PRPF4B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PRPF4B is increased by RRE PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human PRP4 pre-mRNA processing factor 4 homolog B (yeast) (PRPF4B) at amino acid residues 105-106 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase PRP4 homolog
Names
PRP4 kinase
PRP4 pre-mRNA processing factor 4 homolog B
PRP4 pre-mRNA-processing factor 4 homolog
dJ1013A10.1 (PRP4 protein kinase homolog)
protein-serine/threonine kinase
NP_003904.3
XP_011513272.1
XP_016866899.1
XP_016866900.1
XP_016866902.1
XP_016866903.1
XP_016866904.1
XP_016866905.1
XP_016866906.1
XP_016866907.1
XP_016866909.1
XP_016866910.1
XP_016866911.1
XP_016866912.1
XP_016866913.1
XP_016866914.1
XP_016866915.1
XP_016866916.1
XP_016866917.1
XP_016866919.1
XP_016866921.1
XP_016866922.1
XP_016866923.1
XP_016866924.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003913.5NP_003904.3  serine/threonine-protein kinase PRP4 homolog

    See identical proteins and their annotated locations for NP_003904.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AL033383, AL138831, AY029347, CN314758, CN314761
    Consensus CDS
    CCDS4488.1
    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Related
    ENSP00000337194.6, ENST00000337659.11
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

RNA

  1. NR_146783.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL033383, AL138831
  2. NR_146784.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL033383, AL138831
  3. NR_146785.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL033383, AL138831

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    4021300..4064983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011432.2XP_016866921.1  serine/threonine-protein kinase PRP4 homolog isoform X2

  2. XM_017011434.2XP_016866923.1  serine/threonine-protein kinase PRP4 homolog isoform X2

  3. XM_017011433.2XP_016866922.1  serine/threonine-protein kinase PRP4 homolog isoform X2

  4. XM_017011435.2XP_016866924.1  serine/threonine-protein kinase PRP4 homolog isoform X2

  5. XM_017011410.2XP_016866899.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  6. XM_017011411.2XP_016866900.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  7. XM_017011413.2XP_016866902.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  8. XM_017011414.2XP_016866903.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Related
    ENSP00000433547.1, ENST00000480058.5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  9. XM_017011416.2XP_016866905.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  10. XM_017011415.2XP_016866904.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  11. XM_017011417.2XP_016866906.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  12. XM_017011420.2XP_016866909.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  13. XM_017011422.2XP_016866911.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  14. XM_017011423.2XP_016866912.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  15. XM_017011425.2XP_016866914.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  16. XM_017011418.2XP_016866907.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  17. XM_017011421.2XP_016866910.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  18. XM_017011424.2XP_016866913.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  19. XM_017011426.2XP_016866915.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  20. XM_017011427.2XP_016866916.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  21. XM_017011428.2XP_016866917.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  22. XM_017011430.2XP_016866919.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q13523
    UniProtKB/TrEMBL
    A0A024QZY5
    Conserved Domains (2) summary
    smart00220
    Location:6941003
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:6861003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
  23. XM_011514970.3XP_011513272.1  serine/threonine-protein kinase PRP4 homolog isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:686822
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176800.2: Suppressed sequence

    Description
    NM_176800.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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