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BUD31 BUD31 homolog [ Homo sapiens (human) ]

Gene ID: 8896, updated on 9-Jun-2025
Official Symbol
BUD31provided by HGNC
Official Full Name
BUD31 homologprovided by HGNC
Primary source
HGNC:HGNC:29629
See related
Ensembl:ENSG00000106245 MIM:603477; AllianceGenome:HGNC:29629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G10; EDG2; Cwc14; EDG-2; fSAP17; YCR063W
Summary
Enables nuclear receptor binding activity and transcription coactivator activity. Involved in mRNA splicing, via spliceosome. Located in centrosome; chromatin; and nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in testis (RPKM 25.3), bone marrow (RPKM 23.9) and 25 other tissues See more
Orthologs
NEW
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See BUD31 in Genome Data Viewer
Location:
7q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99408969..99419616)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100647870..100658517)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99006592..99017239)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98923087-98923646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18405 Neighboring gene actin related protein 2/3 complex subunit 1A Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98955605-98956105 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98957299-98957799 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:98962524-98962729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98966657-98967570 Neighboring gene Sharpr-MPRA regulatory region 4482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98970933-98971433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18406 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26313 Neighboring gene actin related protein 2/3 complex subunit 1B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98991459-98992130 Neighboring gene PDGFA associated protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26314 Neighboring gene uncharacterized LOC124901707 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18409 Neighboring gene ATP5MF-PTCD1 readthrough Neighboring gene microRNA 12119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99020619-99021120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99027477-99028073 Neighboring gene pentatricopeptide repeat domain 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99032915-99033062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99034189-99034714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18410 Neighboring gene SAP domain containing ribonucleoprotein pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99049670-99050230 Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99053345-99054147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99058948-99059448 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99062959-99063576 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99063577-99064192 Neighboring gene ATP synthase membrane subunit f

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human BUD31 homolog (S. cerevisiae) (BUD31) at amino acid residues 17-18 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC111202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein BUD31 homolog
Names
G10 maternal transcript homolog
functional spliceosome-associated protein 17
maternal G10 transcript
protein EDG-2
protein G10 homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370407.1NP_001357336.1  protein BUD31 homolog

    Status: VALIDATED

    Source sequence(s)
    AC004922
    Consensus CDS
    CCDS5663.1
    UniProtKB/Swiss-Prot
    A4D274, B7Z4S9, D6W5S6, P41223, Q6IB53, Q9UDV1
    Related
    ENSP00000386023.2, ENST00000403633.6
    Conserved Domains (1) summary
    pfam01125
    Location:1143
    G10; G10 protein
  2. NM_001370410.1NP_001357339.1  protein BUD31 homolog

    Status: VALIDATED

    Source sequence(s)
    AC004922
    Consensus CDS
    CCDS5663.1
    UniProtKB/Swiss-Prot
    A4D274, B7Z4S9, D6W5S6, P41223, Q6IB53, Q9UDV1
    Conserved Domains (1) summary
    pfam01125
    Location:1143
    G10; G10 protein
  3. NM_003910.4NP_003901.2  protein BUD31 homolog

    See identical proteins and their annotated locations for NP_003901.2

    Status: VALIDATED

    Source sequence(s)
    AC004922, BC022821
    Consensus CDS
    CCDS5663.1
    UniProtKB/Swiss-Prot
    A4D274, B7Z4S9, D6W5S6, P41223, Q6IB53, Q9UDV1
    Related
    ENSP00000222969.5, ENST00000222969.10
    Conserved Domains (1) summary
    pfam01125
    Location:1143
    G10; G10 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99408969..99419616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421006.1XP_047276962.1  protein BUD31 homolog isoform X2

    UniProtKB/Swiss-Prot
    A4D274, B7Z4S9, D6W5S6, P41223, Q6IB53, Q9UDV1
  2. XM_047421007.1XP_047276963.1  protein BUD31 homolog isoform X3

  3. XM_047421008.1XP_047276964.1  protein BUD31 homolog isoform X3

  4. XM_005250670.6XP_005250727.1  protein BUD31 homolog isoform X1

    See identical proteins and their annotated locations for XP_005250727.1

    UniProtKB/Swiss-Prot
    P41223
    Conserved Domains (1) summary
    pfam01125
    Location:1134
    G10; G10 protein
  5. XM_017012761.3XP_016868250.1  protein BUD31 homolog isoform X1

    UniProtKB/Swiss-Prot
    P41223
    Conserved Domains (1) summary
    pfam01125
    Location:1134
    G10; G10 protein
  6. XM_005250671.6XP_005250728.1  protein BUD31 homolog isoform X1

    See identical proteins and their annotated locations for XP_005250728.1

    UniProtKB/Swiss-Prot
    P41223
    Conserved Domains (1) summary
    pfam01125
    Location:1134
    G10; G10 protein
  7. XM_017012760.3XP_016868249.1  protein BUD31 homolog isoform X1

    UniProtKB/Swiss-Prot
    P41223
    Conserved Domains (1) summary
    pfam01125
    Location:1134
    G10; G10 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100647870..100658517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359290.1XP_054215265.1  protein BUD31 homolog isoform X2

    UniProtKB/Swiss-Prot
    A4D274, B7Z4S9, D6W5S6, P41223, Q6IB53, Q9UDV1
  2. XM_054359291.1XP_054215266.1  protein BUD31 homolog isoform X3

  3. XM_054359292.1XP_054215267.1  protein BUD31 homolog isoform X3

  4. XM_054359287.1XP_054215262.1  protein BUD31 homolog isoform X1

  5. XM_054359289.1XP_054215264.1  protein BUD31 homolog isoform X1

  6. XM_054359286.1XP_054215261.1  protein BUD31 homolog isoform X1

  7. XM_054359288.1XP_054215263.1  protein BUD31 homolog isoform X1