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CPNE3 copine 3 [ Homo sapiens (human) ]

Gene ID: 8895, updated on 21-Dec-2019

Summary

Official Symbol
CPNE3provided by HGNC
Official Full Name
copine 3provided by HGNC
Primary source
HGNC:HGNC:2316
See related
Ensembl:ENSG00000085719 MIM:604207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPN3; PRO1071
Summary
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in thyroid (RPKM 40.1), esophagus (RPKM 38.1) and 25 other tissues See more
Orthologs

Genomic context

See CPNE3 in Genome Data Viewer
Location:
8q21.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (86514422..86561498)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (87526656..87573726)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene regulator of microtubule dynamics 1 Neighboring gene N-terminal asparagine amidase pseudogene 2 Neighboring gene solute carrier family 2 member 3 pseudogene 4 Neighboring gene cyclic nucleotide gated channel subunit beta 3 Neighboring gene myo-inositol oxygenase pseudogene 1 Neighboring gene GOLGA2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify copine III (CPNE3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify copine III (CPNE3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify copine III (CPNE3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify copine III (CPNE3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0636

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ERBB2 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ERBB2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
glycerophospholipid biosynthetic process TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003909.5NP_003900.1  copine-3

    See identical proteins and their annotated locations for NP_003900.1

    Status: REVIEWED

    Source sequence(s)
    AC013751, AC103817, AF077226, AI031907, DB135485
    Consensus CDS
    CCDS6243.1
    UniProtKB/Swiss-Prot
    O75131
    UniProtKB/TrEMBL
    A0A024R994
    Related
    ENSP00000477590.1, ENST00000517490.6
    Conserved Domains (3) summary
    cd04047
    Location:139251
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:7125
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:310527
    Copine; Copine

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    86514422..86561498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013945.2XP_016869434.1  copine-3 isoform X1

    UniProtKB/Swiss-Prot
    O75131
    UniProtKB/TrEMBL
    A0A024R994
    Conserved Domains (3) summary
    cd04047
    Location:139251
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:7125
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:310527
    Copine; Copine
  2. XM_024447322.1XP_024303090.1  copine-3 isoform X1

    Conserved Domains (3) summary
    cd04047
    Location:139251
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:7125
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:310527
    Copine; Copine
  3. XM_005251093.4XP_005251150.1  copine-3 isoform X1

    See identical proteins and their annotated locations for XP_005251150.1

    UniProtKB/Swiss-Prot
    O75131
    UniProtKB/TrEMBL
    A0A024R994
    Conserved Domains (3) summary
    cd04047
    Location:139251
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:7125
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:310527
    Copine; Copine
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