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EIF2S2 eukaryotic translation initiation factor 2 subunit beta [ Homo sapiens (human) ]

Gene ID: 8894, updated on 21-Dec-2019

Summary

Official Symbol
EIF2S2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 2 subunit betaprovided by HGNC
Primary source
HGNC:HGNC:3266
See related
Ensembl:ENSG00000125977 MIM:603908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF2; EIF2B; PPP1R67; EIF2beta; eIF-2-beta
Summary
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in placenta (RPKM 24.2), thyroid (RPKM 22.6) and 25 other tissues See more
Orthologs

Genomic context

See EIF2S2 in Genome Data Viewer
Location:
20q11.22
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (34088309..34112243, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (32676115..32700085, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RALY antisense RNA 1 Neighboring gene RALY heterogeneous nuclear ribonucleoprotein Neighboring gene microRNA 4755 Neighboring gene ribosomal protein S2 pseudogene 1 Neighboring gene agouti signaling protein Neighboring gene exportin for tRNA pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 2 subunit 2 (EIF2S2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with EIF2S2 is increased by RRE PubMed
Tat tat HIV-1 Tat competes with eukaryotic initiation factor 2, a well characterized substrate of PKR, for phosphorylation by activated PKR PubMed
tat Eukaryotic translation initiation factor 2 (eIF2) recognizes and binds the TAR secondary structure in HIV-1 RNA, suggesting a role in Tat transactivation of the viral LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8508, DKFZp686L18198

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
male germ cell proliferation IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 2 complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 2 subunit 2
Names
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
protein phosphatase 1, regulatory subunit 67

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316363.2NP_001303292.1  eukaryotic translation initiation factor 2 subunit 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL031668, BX429051, CA436754, HY005227
    Conserved Domains (1) summary
    smart00653
    Location:196305
    eIF2B_5; domain present in translation initiation factor eIF2B and eIF5
  2. NM_001316364.2NP_001303293.1  eukaryotic translation initiation factor 2 subunit 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL031668, BX418731, CA436754, HY005227
    Conserved Domains (1) summary
    smart00653
    Location:199289
    eIF2B_5; domain present in translation initiation factor eIF2B and eIF5
  3. NM_003908.5NP_003899.2  eukaryotic translation initiation factor 2 subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_003899.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL031668, BC000461, CA436754
    Consensus CDS
    CCDS13231.1
    UniProtKB/Swiss-Prot
    P20042
    UniProtKB/TrEMBL
    Q6IBR8
    Related
    ENSP00000364119.2, ENST00000374980.3
    Conserved Domains (1) summary
    smart00653
    Location:199308
    eIF2B_5; domain present in translation initiation factor eIF2B and eIF5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    34088309..34112243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028118.1XP_016883607.1  eukaryotic translation initiation factor 2 subunit 2 isoform X1

    Conserved Domains (1) summary
    smart00653
    Location:194303
    eIF2B_5; domain present in translation initiation factor eIF2B and eIF5
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