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EIF2B2 eukaryotic translation initiation factor 2B subunit beta [ Homo sapiens (human) ]

Gene ID: 8892, updated on 7-Jun-2020

Summary

Official Symbol
EIF2B2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 2B subunit betaprovided by HGNC
Primary source
HGNC:HGNC:3258
See related
Ensembl:ENSG00000119718 MIM:606454
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF2B; EIF-2Bbeta
Summary
This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in thyroid (RPKM 32.7), adrenal (RPKM 18.1) and 25 other tissues See more
Orthologs

Genomic context

See EIF2B2 in Genome Data Viewer
Location:
14q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (75002921..75012366)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75469612..75476294)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984689 Neighboring gene uncharacterized LOC107984690 Neighboring gene placental growth factor Neighboring gene RNA, U6 small nuclear 689, pseudogene Neighboring gene mutL homolog 3 Neighboring gene acylphosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of translational initiation TAS
Traceable Author Statement
more info
PubMed 
response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
response to heat TAS
Traceable Author Statement
more info
PubMed 
response to peptide hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 2B complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
translation initiation factor eIF-2B subunit beta
Names
S20I15
S20III15
eIF-2B GDP-GTP exchange factor subunit beta
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013333.1 RefSeqGene

    Range
    5001..11683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014239.4NP_055054.1  translation initiation factor eIF-2B subunit beta

    See identical proteins and their annotated locations for NP_055054.1

    Status: REVIEWED

    Source sequence(s)
    AI265790, AL049780, BC011750
    Consensus CDS
    CCDS9836.1
    UniProtKB/Swiss-Prot
    P49770
    UniProtKB/TrEMBL
    Q53XC2
    Related
    ENSP00000266126.5, ENST00000266126.10
    Conserved Domains (1) summary
    pfam01008
    Location:29332
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    75002921..75012366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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