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uvrD2 ATP-dependent DNA helicase UvrD [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888902, updated on 6-Oct-2023
Gene symbol
uvrD2
Gene description
ATP-dependent DNA helicase UvrD
Locus tag
Rv3198c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (3569109..3571211, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene ABC transporter ATP-binding protein Neighboring gene transcriptional regulator WhiB7 Neighboring gene glutaredoxin protein Neighboring gene NADH pyrophosphatase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mycobacterium tuberculosis UvrD1 and UvrD2 helicases unwind G-quadruplex DNA. Saha T, et al. FEBS J, 2019 Jun. PMID 30821905
  2. UvrD2 is essential in Mycobacterium tuberculosis, but its helicase activity is not required. Williams A, et al. J Bacteriol, 2011 Sep. PMID 21725019, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UvrD2 was proficient in resolving previously characterized tetramolecular G4 structures in an ATP hydrolysis and single-stranded 3'-tail-dependent manner. The G4 structures were derived from the potential G4 forming sequences present in the M. tuberculosis genome, suggesting an extended role for UvrD2 in resolving G4 DNA structures and maintaining genome integrity via G4 DNA resolution. UvrD2 is less efficient than UvrD1.
    Title: Mycobacterium tuberculosis UvrD1 and UvrD2 helicases unwind G-quadruplex DNA.
  2. UvrD2 is essential in Mycobacterium tuberculosis. The helicase activity of UvrD2, but not its ATPase and DNA translocase activities, is dispensable.
    Title: UvrD2 is essential in Mycobacterium tuberculosis, but its helicase activity is not required.
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Homology

Preferred Names
ATP-dependent DNA helicase UvrD
NP_217714.1
  • Probable UvrD2,ATP dependent DNA helicase II

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3569109..3571211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217714.1 ATP-dependent DNA helicase UvrD [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217714.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E8NRW5
    Conserved Domains (2) summary
    COG0210
    Location:11 → 578
    UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
    pfam00570
    Location:629 → 696
    HRDC; HRDC domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMP9.1

Gene LinkOut

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