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Rv3131 NAD(P)H nitroreductase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888838, updated on 6-Jun-2024

Summary

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Gene symbol
Rv3131
Gene description
NAD(P)H nitroreductase
Locus tag
Rv3131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3496551..3497549)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene diacyglycerol O-acyltransferase Neighboring gene two component sensor histidine kinase DevS Neighboring gene two component transcriptional regulator DevR Neighboring gene universal stress protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K. Kwon KW, et al. Sci Rep, 2017 Mar 8. PMID 28272457, Free PMC Article
  2. Powerful induction of divergent tgs1-Rv3131 genes in Mycobacterium tuberculosis is mediated by DevR interaction with a high-affinity site and an adjacent cryptic low-affinity site. Chauhan S, et al. J Bacteriol, 2009 Oct. PMID 19648251, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rv3131/GLA-SE-immunised group exhibited a significant reduction in bacterial number and less extensive lung inflammation accompanied by the obvious persistence of Rv3131-specific multifunctional CD4(+) T cells. These results suggest that Rv3131 could be an excellent candidate for potential use in a multi-antigenic Mtb subunit vaccine, especially against Mtb Beijing strains.
    Title: Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K.
  2. DevR interaction with two binding sites is obligatory for synergistic activation of tgs1-Rv3131 promoters.
    Title: Powerful induction of divergent tgs1-Rv3131 genes in Mycobacterium tuberculosis is mediated by DevR interaction with a high-affinity site and an adjacent cryptic low-affinity site.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
NAD(P)H nitroreductase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3496551..3497549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217647.3 NAD(P)H nitroreductase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217647.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    L0TD88, P95195, P9WIZ6, P9WIZ7, Q7D627
    Conserved Domains (1) summary
    PRK07877
    Location:6 → 323
    PRK07877; Rv1355c family protein
Nucleotide Protein
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