U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cyp51 lanosterol 14-alpha demethylase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888819, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
cyp51
Gene description
lanosterol 14-alpha demethylase
Locus tag
Rv0764c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (856682..858037, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ferredoxin Neighboring gene oxidoreductase Neighboring gene cytochrome P450 Cyp123 Neighboring gene HTH-type transcriptional regulator Neighboring gene aldehyde dehydrogenase AldA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Multiple drug binding modes in Mycobacterium tuberculosis CYP51B1. Lockart MM, et al. J Inorg Biochem, 2020 Apr. PMID 31982812, Free PMC Article
  2. Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET. Lepesheva GI, et al. Arch Biochem Biophys, 2007 Aug 15. PMID 17585868, Free PMC Article
  3. Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions. McLean KJ, et al. Biochemistry, 2006 Jul 11. PMID 16819841
  4. MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51. Zanno A, et al. Biochim Biophys Acta, 2005 Apr-May. PMID 15863094
  5. Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis. Matsuura K, et al. J Biol Chem, 2005 Mar 11. PMID 15611056

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple drug binding modes in Mycobacterium tuberculosis CYP51B1.
    Title: Multiple drug binding modes in Mycobacterium tuberculosis CYP51B1.
  2. The results confirm (1) functional importance of conformational motions in the MTCYP51 F/G segment and (2) applicability of FRET to monitor them in solution.
    Title: Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.
  3. CYP51 was purified to homogeneity and characterized.
    Title: Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
  4. Plays primary roles in determining strength of interactions with azoles
    Title: Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis.
  5. MT FdR forms a complex with MT ferredoxin and MT CYP51 that transfers electrons and effects the demethylation of lanosterol
    Title: MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
lanosterol 14-alpha demethylase
NP_215278.1
  • Cytochrome P450 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    856682..858037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215278.1 lanosterol 14-alpha demethylase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215278.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M3H8
    Conserved Domains (1) summary
    cd11042
    Location:34 → 446
    CYP51-like; cytochrome P450 family 51 and similar cytochrome P450s
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPP9.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials