U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

phoP two component system response transcriptional positive regulator PhoP [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888772, updated on 5-Jun-2024
Gene symbol
phoP
Gene description
two component system response transcriptional positive regulator PhoP
Locus tag
Rv0757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000962.3 (851608..852351)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene tRNA-Thr Neighboring gene two component system response sensor kinase PhoR Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptional activation of the Mycobacterium tuberculosis virulence-associated small RNA MTS1338 by the response regulators DosR and PhoP.
    Title: Transcriptional activation of the Mycobacterium tuberculosis virulence-associated small RNA MTS1338 by the response regulators DosR and PhoP.
  2. PhoP, a virulence regulator of the tubercle bacilli, controls heat shock-responsive genes, an essential pathogenic determinant of M. tuberculosis
    Title: Functioning of Mycobacterial Heat Shock Repressors Requires the Master Virulence Regulator PhoP.
  3. Both MprA and PhoP can directly bind to the promoter of phoP and MprA positively regulates phoP expression. Reveal a new binding motif for MprA in the phoP promoter.
    Title: Novel MprA binding motifs in the phoP regulatory region in Mycobacterium tuberculosis.
  4. DevR forms a heterodimer with PhoPRv; puts forward a new possible mechanism for coordinated expression of the dormancy regulon
    Title: Interplay of PhoP and DevR response regulators defines expression of the dormancy regulon in virulent Mycobacterium tuberculosis.
  5. In this study, we found that PhoPR directly activates whiB3 expression in response to low pH.
    Title: PhoPR Positively Regulates whiB3 Expression in Response to Low pH in Pathogenic Mycobacteria.
  6. PhoP is essential for virulence as a response regulator involved in cell wall lipid biosynthesis and regulation of gene expression.[review]
    Title: [Mycobacterium tuberculosis PhoP system].
  7. a model is proposed suggesting how PhoP and EspR protein-protein interactions contribute to activation of espACD expression and, in turn, control ESAT-6 secretion, an essential pathogenic determinant of M. tuberculosis
    Title: EspR-dependent ESAT-6 Protein Secretion of Mycobacterium tuberculosis Requires the Presence of Virulence Regulator PhoP.
  8. EspR is directly regulated by the two-component systems MprAB and PhoPR.
    Title: EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR.
  9. Identified a high-affinity DNA sequence for PhoP binding using systematic evolution of ligands by exponential enrichment. The sequence contains a direct repeat of two 7 bp motifs separated by a 4 bp spacer, TCACAGC(N4)TCACAGC.
    Title: DNA consensus sequence motif for binding response regulator PhoP, a virulence regulator of Mycobacterium tuberculosis.
  10. DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system, were identified.
    Title: Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Homology

Preferred Names
two component system response transcriptional positive regulator PhoP

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    851608..852351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215271.1 two component system response transcriptional positive regulator PhoP [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215271.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655JDP8
    Conserved Domains (1) summary
    COG0745
    Location:22 → 246
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials