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mtrA two component DNA-binding response regulator MtrA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888743, updated on 6-Oct-2023
Gene symbol
mtrA
Gene description
two component DNA-binding response regulator MtrA
Locus tag
Rv3246c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (3626663..3627349, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene lipoprotein LpqB Neighboring gene two component sensory histidine kinase MtrB Neighboring gene thymidylate kinase Neighboring gene adenosylhomocysteinase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Methylation of two-component response regulator MtrA in mycobacteria negatively modulates its DNA binding and transcriptional activation. Singhal A, et al. Biochem J, 2020 Dec 11. PMID 33175092, Free PMC Article
  2. The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis. Li Y, et al. BMC Microbiol, 2010 Sep 16. PMID 20843371, Free PMC Article
  3. Global mapping of MtrA-binding sites links MtrA to regulation of its targets in Mycobacterium tuberculosis. Chatterjee A, et al. Microbiology (Reading), 2018 Jan. PMID 29182512
  4. Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation. Friedland N, et al. Biochemistry, 2007 Jun 12. PMID 17511470, Free PMC Article
  5. Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator. Fol M, et al. Mol Microbiol, 2006 May. PMID 16629667

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methylation of two-component response regulator MtrA in mycobacteria negatively modulates its DNA binding and transcriptional activation.
    Title: Methylation of two-component response regulator MtrA in mycobacteria negatively modulates its DNA binding and transcriptional activation.
  2. Two component DNA-binding response regulator MtrA (MtrA) binds upstream of at least 45 target genes of Mycobacterium tuberculosis, including those involved in cell wall remodelling, stress responses, persistence and regulation of transcription. Phosphorylation of MtrA (MtrA-P) is required for the expression of its targets in macrophages.
    Title: Global mapping of MtrA-binding sites links MtrA to regulation of its targets in Mycobacterium tuberculosis.
  3. These experiments suggest that MtrA functions as a repressor of rpfB transcription.
    Title: MtrA, an essential response regulator of the MtrAB two-component system, regulates the transcription of resuscitation-promoting factor B of Mycobacterium tuberculosis.
  4. Data suggest that MtrB septal association is a necessary feature of MtrB activation that promotes MtrA phosphorylation and MtrA regulon expression
    Title: Septal localization of the Mycobacterium tuberculosis MtrB sensor kinase promotes MtrA regulon expression.
  5. Approximately 420 target genes potentially regulated by MtrA.
    Title: The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis.
  6. Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator.
    Title: Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator.
  7. The domain orientation exhibited by MtrA also provides a rationale for the variation in linker length that is observed within the family of bacterial response regulators.
    Title: Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation.
  8. Proliferation of M. tuberculosis in vivo depends, in part, on the optimal ratio of phosphorylated to non-phosphorylated MtrA response regulator
    Title: Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator.
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Homology

Preferred Names
two component DNA-binding response regulator MtrA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3626663..3627349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217763.1 two component DNA-binding response regulator MtrA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217763.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WC56
    Conserved Domains (1) summary
    COG0745
    Location:7 → 228
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WGM7.1

Gene LinkOut

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