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blaC beta-lactamase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888742, updated on 6-Oct-2023
Gene symbol
blaC
Gene description
beta-lactamase
Locus tag
Rv2068c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2325886..2326809, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene precorrin-8X methylmutase Neighboring gene bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase Neighboring gene hypothetical protein Neighboring gene ECF RNA polymerase sigma factor SigC Neighboring gene precorrin-6A reductase Neighboring gene precorrin-4 C(11)-methyltransferase Neighboring gene precorrin-6Y C(5,15)-methyltransferase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam. van Alen I, et al. Biochemistry, 2021 Jul 20. PMID 34250791, Free PMC Article
  2. Evaluating the covalent binding of carbapenems on BlaC using noncovalent interactions. Sun L, et al. J Mol Model, 2021 May 8. PMID 33966119
  3. Crystal Structure of Phosphoserine BlaC from Mycobacterium tuberculosis Inactivated by Bis(Benzoyl) Phosphate. Moural TW, et al. Int J Mol Sci, 2019 Jul 2. PMID 31269656, Free PMC Article
  4. Kinetic characterization of hydrolysis of nitrocefin, cefoxitin, and meropenem by β-lactamase from Mycobacterium tuberculosis. Chow C, et al. Biochemistry, 2013 Jun 11. PMID 23672214, Free PMC Article
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam.
    Title: The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam.
  2. Evaluating the covalent binding of carbapenems on BlaC using noncovalent interactions.
    Title: Evaluating the covalent binding of carbapenems on BlaC using noncovalent interactions.
  3. This study conducted protein X-ray crystallographic analysis of the inactivation of BlaC, upon exposure to the inhibitor bis(benzoyl) phosphate.
    Title: Crystal Structure of Phosphoserine BlaC from Mycobacterium tuberculosis Inactivated by Bis(Benzoyl) Phosphate.
  4. The rate-limiting steps and chemical mechanism of the BlaC-catalyzed hydrolysis of beta-lactam substrates.
    Title: Kinetic characterization of hydrolysis of nitrocefin, cefoxitin, and meropenem by β-lactamase from Mycobacterium tuberculosis.
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Homology

Preferred Names
beta-lactamase
NP_216584.1
  • class A

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2325886..2326809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216584.1 beta-lactamase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216584.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M3D8
    Conserved Domains (1) summary
    COG2367
    Location:7 → 307
    PenP; Beta-lactamase class A [Defense mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WKD3.1

Gene LinkOut

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Molecular Biology Databases
Research Materials