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DDX18 DEAD-box helicase 18 [ Homo sapiens (human) ]

Gene ID: 8886, updated on 4-Jun-2020

Summary

Official Symbol
DDX18provided by HGNC
Official Full Name
DEAD-box helicase 18provided by HGNC
Primary source
HGNC:HGNC:2741
See related
Ensembl:ENSG00000088205 MIM:606355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Has1; MrDb
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 23.5), thyroid (RPKM 21.0) and 25 other tissues See more
Orthologs

Genomic context

See DDX18 in Genome Data Viewer
Location:
2q14.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (117814691..117832377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (118572255..118589953)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MT-CO1 pseudogene 43 Neighboring gene RNA, U7 small nuclear 190 pseudogene Neighboring gene Sharpr-MPRA regulatory region 195 Neighboring gene uncharacterized LOC107985939 Neighboring gene 5-hydroxytryptamine receptor 5B, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 (DDX18) at amino acid residues 35-36 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33908

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX18
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DEAD box protein 18
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated)
Myc-regulated DEAD box protein
NP_006764.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006773.4NP_006764.3  ATP-dependent RNA helicase DDX18

    See identical proteins and their annotated locations for NP_006764.3

    Status: REVIEWED

    Source sequence(s)
    AK091227, BC024739, BU599536
    Consensus CDS
    CCDS2120.1
    UniProtKB/Swiss-Prot
    Q9NVP1
    UniProtKB/TrEMBL
    A0A024RAH8, Q8N254
    Related
    ENSP00000263239.2, ENST00000263239.7
    Conserved Domains (4) summary
    smart00487
    Location:194382
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:400529
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:179386
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:561619
    DUF4217; Domain of unknown function (DUF4217)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    117814691..117832377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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