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hrp1 hypoxic response protein [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888576, updated on 12-Jun-2021

Summary

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Gene symbol
hrp1
Gene description
hypoxic response protein
Locus tag
Rv2626c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2952562..2952993, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene universal stress protein Neighboring gene zinc metalloprotease Rip3 Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Preliminary Study on the Secretory Performance of Mycobacterium tuberculosis Hypoxic Response Protein 1 (Rv2626c)]. Ni WY, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2020 Sep. PMID 32975083
  2. Mycobacterium tuberculosis hypoxic response protein 1 (Hrp1) augments the pro-inflammatory response and enhances the survival of Mycobacterium smegmatis in murine macrophages. Sun C, et al. J Med Microbiol, 2017 Jul. PMID 28671529
  3. Chlamydial polymorphic membrane proteins: regulation, function and potential vaccine candidates. Vasilevsky S, et al. Virulence, 2016. PMID 26580416, Free PMC Article
  4. Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions. Bashir N, et al. Immunology, 2010 May. PMID 20201990, Free PMC Article
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Preliminary Study on the Secretory Performance of Mycobacterium tuberculosis Hypoxic Response Protein 1 (Rv2626c)].
    Title: [Preliminary Study on the Secretory Performance of Mycobacterium tuberculosis Hypoxic Response Protein 1 (Rv2626c)].
  2. Mycobacterium tuberculosis protein Rv2626c plays a significant role in stimulating macrophages to provoke a pro-inflammatory response and in mycobacterial survival during infection.
    Title: Mycobacterium tuberculosis hypoxic response protein 1 (Hrp1) augments the pro-inflammatory response and enhances the survival of Mycobacterium smegmatis in murine macrophages.
  3. PPE68 protein interacts and exports several unknown or known surface/secreted proteins, among them Rv2626c is associated with the host cell necrosis.
    Title: Chlamydial polymorphic membrane proteins: regulation, function and potential vaccine candidates.
  4. Rv2626c \appears to modulate macrophage effector functions by eliciting both innate and adaptive immune responses
    Title: Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions.
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General gene information

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Homology

General protein information

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Preferred Names
hypoxic response protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2952562..2952993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217142.1 hypoxic response protein [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217142.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WJA3
    UniProtKB/TrEMBL
    I6Y193
    Conserved Domains (1) summary
    cd04622
    Location:8 → 122
    CBS_pair_HRP1_like; CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJA3.1

Gene LinkOut

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Molecular Biology Databases