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mapA methionine aminopeptidase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888564, updated on 6-Oct-2023

Summary

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Gene symbol
mapA
Gene description
methionine aminopeptidase
Locus tag
Rv0734
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
map
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Genomic context

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Sequence:
NC_000962.3 (826670..827470)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene preprotein translocase SecY Neighboring gene adenylate kinase Neighboring gene ECF RNA polymerase sigma factor SigL Neighboring gene anti-sigma-L factor RslA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome. Addlagatta A, et al. Biochemistry, 2005 May 17. PMID 15882055
  2. Biochemical characterization of recombinant methionine aminopeptidases (MAPs) from Mycobacterium tuberculosis H37Rv. Narayanan SS, et al. Mol Cell Biochem, 2012 Jun. PMID 22466806
  3. Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv. Zhang X, et al. Curr Microbiol, 2009 Nov. PMID 19688379
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cobalt and nickel are activators of MtbMAP A and MtbMAP B while magnesium was not, site directed mutagenesis also revealed key residues in binding of the metal ions were also identified for both enzymes.
    Title: Biochemical characterization of recombinant methionine aminopeptidases (MAPs) from Mycobacterium tuberculosis H37Rv.
  2. MapA and MapB have different activities in their substrate specificity, divalent ion requirement, and optimal temperature.
    Title: Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv.
  3. The binding of methionine aminopeptidases to the ribosome is mediated by a complex between a Pro-x-x-Pro proline motif on the protein and an src homology 3 (SH3) domain on the ribosome.
    Title: Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
methionine aminopeptidase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    826670..827470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177748.1 methionine aminopeptidase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177748.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3L6G7
    Conserved Domains (1) summary
    PRK05716
    Location:44 → 265
    PRK05716; methionine aminopeptidase; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WK21.1

Gene LinkOut

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