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cyp121 cytochrome P450 Cyp121 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888373, updated on 6-Oct-2023
Gene symbol
cyp121
Gene description
cytochrome P450 Cyp121
Locus tag
Rv2276
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2547749..2548939)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene toxin MazF8 Neighboring gene cyclo(L-tyrosyl-L-tyrosyl) synthase Neighboring gene antitoxin MazE8 Neighboring gene glycerolphosphodiesterase Neighboring gene

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures. Fonvielle M, et al. J Biol Chem, 2013 Jun 14. PMID 23620594, Free PMC Article
  2. Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis. Belin P, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19416919, Free PMC Article
  3. Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv. McLean KJ, et al. J Biol Chem, 2008 Nov 28. PMID 18818197, Free PMC Article
  4. Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode. Seward HE, et al. J Biol Chem, 2006 Dec 22. PMID 17028183
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The specificity of CYP121 results from both a restricted binding specificity and a fine-tuned P450 substrate relationship.
    Title: Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures.
  2. This study provides insight into the catalytic activity, mechanism, and biological function of CYP121.
    Title: Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.
  3. Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.
    Title: Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.
  4. analysis of Mycobacterium tuberculosis P450 CYP121-fluconazole complex
    Title: Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.
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Homology

Preferred Names
cytochrome P450 Cyp121
NP_216792.1
  • mycocyclosin synthase; catalyzes the formation of mycocyclosin from cyclotyrosine

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2547749..2548939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216792.1 cytochrome P450 Cyp121 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216792.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W900
    Conserved Domains (1) summary
    cl41757
    Location:18 → 396
    cytochrome_P450; cytochrome P450 (CYP) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPP7.1

Gene LinkOut

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Molecular Biology Databases