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ftsZ cell division protein FtsZ [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888369, updated on 11-Dec-2020
Gene symbol
ftsZ
Gene description
cell division protein FtsZ
Locus tag
Rv2150c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2408385..2409524, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene cell division protein SepF Neighboring gene hypothetical protein Neighboring gene laccase domain-containing protein Neighboring gene cell division protein FtsQ Neighboring gene UDP-N-acetylmuramate--alanine ligase Neighboring gene UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase Neighboring gene lipid II flippase FtsW

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Novel T9 loop conformation of filamenting temperature-sensitive mutant Z from Mycobacterium tuberculosis. Lazo EO, et al. Acta Crystallogr F Struct Biol Commun, 2019 May 1. PMID 31045565, Free PMC Article
  2. FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation. Li Y, et al. Science, 2013 Jul 26. PMID 23888039, Free PMC Article
  3. The structure, function, and regulation of Mycobacterium FtsZ. Hong W, et al. Cell Biochem Biophys, 2013 Mar. PMID 22932926
  4. Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ. Popp D, et al. J Biol Chem, 2010 Apr 9. PMID 20139085, Free PMC Article
  5. Mycobacterium tuberculosis ftsZ expression and minimal promoter activity. Kiran M, et al. Tuberculosis (Edinb), 2009 Dec. PMID 20006308, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel T9 loop conformation of mutant FtsZ from Mycobacterium tuberculosis has been deciphered.
    Title: Novel T9 loop conformation of filamenting temperature-sensitive mutant Z from Mycobacterium tuberculosis.
  2. SepF of interacts with FtsZ and MurG to regulate cell growth and division.
    Title: Essential protein SepF of mycobacteria interacts with FtsZ and MurG to regulate cell growth and division.
  3. determined crystal structure of a GDP-bound FtsZ protofilament which exhibits curved conformational state; protofilament curvature highlights a hydrolysis-dependent conformational switch at the T3 loop that leads to longitudinal bending between subunits which could generate sufficient force to drive cytokinesis
    Title: FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.
  4. Studies indicate FtsZ as potential novel drug target for anti-tuberculosis therapeutics.
    Title: The structure, function, and regulation of Mycobacterium FtsZ.
  5. We propose that ftsZ expression from all promoters is required for optimal intracellular FtsZ levels and that the activities of P4 and possibly other promoters are down-regulated during growth-arrest conditions.
    Title: Mycobacterium tuberculosis ftsZ expression and minimal promoter activity.
  6. Results suggest that M. tuberculosis ClpX interacts stoichiometrically with FtsZ protomers, independent of its nucleotide-bound state and negatively regulates FtsZ activities, hence cell division.
    Title: Mycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assembly.
  7. analysis of Mycobacterium tuberculosis FtsZ suprastructures and dynamic properties
    Title: Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ.
  8. The results together suggest that the cysteine residue (Cys-155) of MtbFtsZ plays an important role in the assembly of MtbFtsZ into protofilaments.
    Title: Cysteine 155 plays an important role in the assembly of Mycobacterium tuberculosis FtsZ.
  9. analysis of Mycobacterium tuberculosis FtsZ assembly dynamics
    Title: Assembly dynamics of Mycobacterium tuberculosis FtsZ.
  10. assessed the expression of FtsZ, Acr and DevR in the lung granulomas of guinea pigs infected with M. tuberculosis; surprisingly, immunostaining for all three antigens was observed throughout the course of infection
    Title: Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection.
Submit: New GeneRIF Correction See all GeneRIFs (13)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Preferred Names
cell division protein FtsZ

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2408385..2409524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216666.1 cell division protein FtsZ [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216666.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK09330
    Location:22 → 360
    PRK09330; cell division protein FtsZ; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2Q1X_A.1
2Q1X_B.1
2Q1Y_A.1
2Q1Y_B.1
P9WN95.1

Gene LinkOut

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Research Materials