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mce4A Mce family protein Mce4A [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888344, updated on 4-Feb-2024

Summary

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Gene symbol
mce4A
Gene description
Mce family protein Mce4A
Locus tag
Rv3499c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
mce4
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Genomic context

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Sequence:
NC_000962.3 (3917998..3919200, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene Mce family lipoprotein LprN Neighboring gene Mce family protein Mce4D Neighboring gene Mce family protein Mce4C Neighboring gene Mce family protein Mce4B Neighboring gene integral membrane protein Neighboring gene integral membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival. Sinha R, et al. Tuberculosis (Edinb), 2018 Mar. PMID 29559121
  2. Exploring molecular insights into the interaction mechanism of cholesterol derivatives with the Mce4A: A combined spectroscopic and molecular dynamic simulation studies. Khan S, et al. Int J Biol Macromol, 2018 May. PMID 29329815
  3. PDIM and SL1 accumulation in Mycobacterium tuberculosis is associated with mce4A expression. Singh P, et al. Gene, 2018 Feb 5. PMID 28988960
  4. Mce4A protein of Mycobacterium tuberculosis induces pro inflammatory cytokine response leading to macrophage apoptosis in a TNF-α dependent manner. Saini NK, et al. Microb Pathog, 2016 Nov. PMID 27592091
  5. An insight into the regulation of mce4 operon of Mycobacterium tuberculosis. Rathor N, et al. Tuberculosis (Edinb), 2013 Jul. PMID 23622789

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MceG stabilizes the Mce1 and Mce4 transporters in Mycobacterium tuberculosis.
    Title: MceG stabilizes the Mce1 and Mce4 transporters in Mycobacterium tuberculosis.
  2. Rv3499c gene of mce4 operon plays an important role in long term cholesterol-dependent survival of mycobacteria inside the harsh intracellular environment of host macrophages.
    Title: Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival.
  3. This work provides a deeper insight into the mechanism of interaction of Mce4A to cholesterol derivatives, which may be further exploited to design potential and specific inhibitors to ameliorate the Mycobacterium pathogenesis.
    Title: Exploring molecular insights into the interaction mechanism of cholesterol derivatives with the Mce4A: A combined spectroscopic and molecular dynamic simulation studies.
  4. Study provides evidence that expression of mce4A within mce operon acts as a regulatory factor for expression of metabolic pathway required for phthiocerol dimycocerates and sulfolipid accumulation of M. tuberculosis H37Rv.
    Title: PDIM and SL1 accumulation in Mycobacterium tuberculosis is associated with mce4A expression.
  5. In this report the authors present evidence to establish a role for Mce4A in the modulation of THP-1 cell survival.
    Title: Mce4A protein of Mycobacterium tuberculosis induces pro inflammatory cytokine response leading to macrophage apoptosis in a TNF-α dependent manner.
  6. The mce4 operon is reported to be involved in cholesterol utilization and intracellular survival of Mycobacterium tuberculosis
    Title: An insight into the regulation of mce4 operon of Mycobacterium tuberculosis.
  7. Mce4A protein is expressed during the stationary phase and localizes in the cell wall. Expression in non-pathogenic E. coli enables it to enter and survive within HeLa cells and macrophages.
    Title: Characterization of Mce4A protein of Mycobacterium tuberculosis: role in invasion and survival.
  8. These observations suggest that the mce3 and mce4 operons have a role distinct from that of mce1 for in vivo survival of M. tuberculosis.
    Title: Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice.
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General gene information

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Homology

General protein information

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Preferred Names
Mce family protein Mce4A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3917998..3919200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177977.1 Mce family protein Mce4A [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177977.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WD97, A0A655HUK2
    Conserved Domains (1) summary
    TIGR00996
    Location:11 → 300
    Mtu_fam_mce; virulence factor Mce family protein
Nucleotide Protein
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