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clgR transcriptional regulator ClgR [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888315, updated on 6-Oct-2023
Gene symbol
clgR
Gene description
transcriptional regulator ClgR
Locus tag
Rv2745c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (3058193..3058531, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene L-glutamate alpha-N-acetyltranferase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Mycobacterium tuberculosis Clp gene regulator is required for in vitro reactivation from hypoxia-induced dormancy. McGillivray A, et al. J Biol Chem, 2015 Jan 23. PMID 25422323, Free PMC Article
  2. The Mycobacterium tuberculosis Rv2745c plays an important role in responding to redox stress. McGillivray A, et al. PLoS One, 2014. PMID 24705585, Free PMC Article
  3. Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis. Sherrid AM, et al. PLoS One, 2010 Jul 16. PMID 20661284, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Together with the fact that the expression of Rv2745c is strongly induced in response to redox stress, these results strongly implicate a role for ClgR in the management of intraphagosomal redox stress.
    Title: The Mycobacterium tuberculosis Rv2745c plays an important role in responding to redox stress.
  2. the Clp gene regulator Rv2745c is required for in vitro reactivation from hypoxia-induced dormancy
    Title: The Mycobacterium tuberculosis Clp gene regulator is required for in vitro reactivation from hypoxia-induced dormancy.
  3. This study defines a new transcriptional response of MTB with potential relevance to disease, and implicates ClgR (Rv2745c)as a regulator involved in resumption of replication following hypoxia.
    Title: Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis.
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Homology

Preferred Names
transcriptional regulator ClgR
NP_217261.1
  • ClgR,transcriptional regulatory protein, controls protease systems and chaperones.

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3058193..3058531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217261.1 transcriptional regulator ClgR [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217261.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WAH8
    Conserved Domains (1) summary
    cd00093
    Location:10 → 65
    HTH_XRE; Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMH7.1

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