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pncA pyrazinamidase/nicotinamidase PncA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888260, updated on 4-Apr-2024
Gene symbol
pncA
Gene description
pyrazinamidase/nicotinamidase PncA
Locus tag
Rv2043c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Try the new Transcripts and proteins table
Sequence:
NC_000962.3 (2288681..2289241, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene sugar ABC transporter permease Neighboring gene sugar ABC transporter substrate-binding lipoprotein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene carboxylesterase LipT

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The 7H11 Agar Medium Supplemented with Calf Bovine Serum for Susceptibility Testing of Mycobacterium tuberculosis Isolates Against Pyrazinamide. Amini S, et al. Microb Drug Resist, 2021 Dec. PMID 34077245
  2. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil. Rodrigues Vde F, et al. Antimicrob Agents Chemother, 2005 Jan. PMID 15616332, Free PMC Article
  3. Microarray-based pncA genotyping of pyrazinamide-resistant strains of Mycobacterium tuberculosis. Denkin S, et al. J Med Microbiol, 2005 Dec. PMID 16278424
  4. pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates from the southeast region of Brazil. Barco P, et al. J Antimicrob Chemother, 2006 Nov. PMID 16971417
  5. Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase. Zhang H, et al. FEBS J, 2008 Feb. PMID 18201201

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The pncA gene mutations of Mycobacterium tuberculosis in multidrug-resistant tuberculosis.
    Title: The pncA gene mutations of Mycobacterium tuberculosis in multidrug-resistant tuberculosis.
  2. The 7H11 Agar Medium Supplemented with Calf Bovine Serum for Susceptibility Testing of Mycobacterium tuberculosis Isolates Against Pyrazinamide.
    Title: The 7H11 Agar Medium Supplemented with Calf Bovine Serum for Susceptibility Testing of Mycobacterium tuberculosis Isolates Against Pyrazinamide.
  3. PncA mutations correlate with pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis clinical isolates in Myanmar.
    Title: Pyrazinamide Resistance among Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Myanmar.
  4. pncA mutations in multi-drug and pyrazinamide resistant Mycobacterium tuberculosis isolates cultured from Queensland migrants and Papua New Guinea residents suggest that there is likely active transmission of MDR-TB with pyrazinamide resistance within the Western Province.
    Title: Characterization of pncA mutations in multi-drug and pyrazinamide resistant Mycobacterium tuberculosis isolates cultured from Queensland migrants and Papua New Guinea residents.
  5. Study shows that mutation in PncA gene provides resistance to anti-tubercular pyrazinamide.
    Title: Phenotypic and genotypic characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis clinical isolates in Hangzhou, China.
  6. mutation in the 68th residue of protein results in a structural change at its active site which further affects the biological function of protein
    Title: Role of pncA gene mutations W68R and W68G in pyrazinamide resistance.
  7. Mutations of PncA result in loss of enzymatic activity, decrease in protein abundance and confer resistance to pyrazinamide.
    Title: A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.
  8. Overexpression of the pyrazinoic acid(PZA)-activating enzyme PncA can confer PZA susceptibility to M. tuberculosis under neutral and even alkaline growth conditions.
    Title: Uncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosis.
  9. pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 mug/ml pyrazinamide in MGIT within a cohort of isolates from South Africa and the U.S. Centers for Disease Control and Prevention.
    Title: Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT.
  10. Report pncA sequencing to be a more reliable test for detection of pyrazinamide resistance in mycobacterium tuberculosis.
    Title: Resistance to pyrazinamide in Russian Mycobacterium tuberculosis isolates: pncA sequencing versus Bactec MGIT 960.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Homology

Preferred Names
pyrazinamidase/nicotinamidase PncA
NP_216559.1
  • involved in susceptibility or resistance to antituberculous drug pyrazinamide.

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2288681..2289241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216559.1 pyrazinamidase/nicotinamidase PncA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216559.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H4LHR5, A0A509ENS5, A0A509EPA2, A0A509EQI0, A0A509ER68, A0A509ERA9, H2D4C2, Q5UFH2, Q5UFI5
    Conserved Domains (1) summary
    cd01011
    Location:1 → 183
    nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3PL1_A.1
I6XD65.1

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