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wag31 cell wall synthesis protein Wag31 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888224, updated on 6-Oct-2023

Summary

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Gene symbol
wag31
Gene description
cell wall synthesis protein Wag31
Locus tag
Rv2145c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
ag84
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Genomic context

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Sequence:
NC_000962.3 (2404616..2405398, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene transmembrane protein Neighboring gene transmembrane protein Neighboring gene cell division protein SepF Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterium tuberculosis Rv2145c Promotes Intracellular Survival by STAT3 and IL-10 Receptor Signaling. Park HS, et al. Front Immunol, 2021. PMID 34017340, Free PMC Article
  2. Higher order assembling of the mycobacterial polar growth factor DivIVA/Wag31. Choukate K, et al. J Struct Biol, 2020 Feb 1. PMID 31778770
  3. Direct Interaction of Polar Scaffolding Protein Wag31 with Nucleoid-Associated Protein Rv3852 Regulates Its Polar Localization. Garg R, et al. Cells, 2021 Jun 20. PMID 34203111, Free PMC Article
  4. Modulation of human T cell cytokines by the Mycobacterium tuberculosis-secreted protein Wag31. Samten B, et al. Tuberculosis (Edinb), 2016 Dec. PMID 27742462
  5. The wag31 gene of Mycobacterium tuberculosis is positively regulated by the stringent response. Dahl JL, et al. FEMS Microbiol Lett, 2011 Jun. PMID 21470298

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct Interaction of Polar Scaffolding Protein Wag31 with Nucleoid-Associated Protein Rv3852 Regulates Its Polar Localization.
    Title: Direct Interaction of Polar Scaffolding Protein Wag31 with Nucleoid-Associated Protein Rv3852 Regulates Its Polar Localization.
  2. Mycobacterium tuberculosis Rv2145c Promotes Intracellular Survival by STAT3 and IL-10 Receptor Signaling.
    Title: Mycobacterium tuberculosis Rv2145c Promotes Intracellular Survival by STAT3 and IL-10 Receptor Signaling.
  3. Higher order assembling of the mycobacterial polar growth factor DivIVA/Wag31.
    Title: Higher order assembling of the mycobacterial polar growth factor DivIVA/Wag31.
  4. Wag31 may modulate human T cell immune responses during tuberculosis infection through its C-terminal domain.
    Title: Modulation of human T cell cytokines by the Mycobacterium tuberculosis-secreted protein Wag31.
  5. Interaction between PknA and Wag31 is dependent on the phos- phorylation state of Wag31.
    Title: Phosphorylation-dependent interaction between a serine/threonine kinase PknA and a putative cell division protein Wag31 in Mycobacterium tuberculosis.
  6. 4 proteins( (GrpE, CanB, MoxR1 and Eis) were highly expressed, with two of them (Wag31 and GroES) being uniquely expressed under anaerobic conditions
    Title: Suppression of Eis and expression of Wag31 and GroES in Mycobacterium tuberculosis cytosol under anaerobic culture conditions.
  7. Because CrgA and Wag31 proteins interact with FtsI individually, the authors believe that regulated cell wall synthesis and cell shape maintenance require the concerted actions of the CrgA, Rv0008c, FtsI, and Wag31 proteins.
    Title: Mycobacterium tuberculosis CwsA interacts with CrgA and Wag31, and the CrgA-CwsA complex is involved in peptidoglycan synthesis and cell shape determination.
  8. Wag31 is upregulated in a rel-dependent manner.
    Title: The wag31 gene of Mycobacterium tuberculosis is positively regulated by the stringent response.
  9. Wag31 was found to specifically stimulate XCL2 expression in macrophages
    Title: Mycobacterium tuberculosis antigen Wag31 induces expression of C-chemokine XCL2 in macrophages.
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General gene information

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Homology

General protein information

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Preferred Names
cell wall synthesis protein Wag31

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2404616..2405398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216661.1 cell wall synthesis protein Wag31 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216661.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M755
    Conserved Domains (1) summary
    COG3599
    Location:4 → 215
    DivIVA; Cell division septum initiation DivIVA, interacts with FtsZ, MinD and other proteins [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMU1.1

Gene LinkOut

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Research Materials