U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

clpX ATP-dependent CLP protease ATP-binding subunit ClpX [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888167, updated on 6-Oct-2023
Gene symbol
clpX
Gene description
ATP-dependent CLP protease ATP-binding subunit ClpX
Locus tag
Rv2457c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000962.3 (2758208..2759488, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate oxidoreductase subunit KorB Neighboring gene 2-oxoglutarate oxidoreductase subunit KorA Neighboring gene MFS-type transporter Neighboring gene homocysteine S-methyltransferase MmuM Neighboring gene MFS-type transporter

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assembly. Dziedzic R, et al. PLoS One, 2010 Jul 6. PMID 20625433, Free PMC Article
  2. ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis. Texier P, et al. J Mol Biol, 2021 Mar 5. PMID 33450247
  3. Selectivity among Anti-σ Factors by Mycobacterium tuberculosis ClpX Influences Intracellular Levels of Extracytoplasmic Function σ Factors. Joshi AC, et al. J Bacteriol, 2019 Mar 15. PMID 30617240, Free PMC Article
  4. Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase. Schmitz KR, et al. Mol Microbiol, 2014 Aug. PMID 24976069, Free PMC Article
  5. The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1. Leodolter J, et al. PLoS One, 2015. PMID 25933022, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis.
    Title: ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis.
  2. Release of the sigma factor from the anti-sigma is governed by the ClpXP2P1 assembly. Mycobacterium tuberculosis extracytoplasmic function anti-sigma factors have an ssrA-like degron for targeted degradation.
    Title: Selectivity among Anti-σ Factors by Mycobacterium tuberculosis ClpX Influences Intracellular Levels of Extracytoplasmic Function σ Factors.
  3. The Mycobacterium tuberculosis ClpP1-ClpP2 protease interacts asymmetrically with its ATPase partners ClpX and ClpC1.
    Title: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
  4. Both ClpX and ClpC1 catalyse ATP-dependent unfolding and degradation of native protein substrates in conjunction with ClpP1P2, but neither mediates protein degradation with just ClpP1 or ClpP2.
    Title: Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase.
  5. Results suggest that M. tuberculosis ClpX interacts stoichiometrically with FtsZ protomers, independent of its nucleotide-bound state and negatively regulates FtsZ activities, hence cell division.
    Title: Mycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assembly.
Submit: New GeneRIF Correction

Homology

Preferred Names
ATP-dependent CLP protease ATP-binding subunit ClpX

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2758208..2759488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216973.1 ATP-dependent CLP protease ATP-binding subunit ClpX [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216973.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W9K4
    Conserved Domains (1) summary
    PRK05342
    Location:2 → 417
    clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPB9.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases