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mutT1 8-oxo-dGTP diphosphatase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888165, updated on 4-Apr-2024

Summary

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Gene symbol
mutT1
Gene description
8-oxo-dGTP diphosphatase
Locus tag
Rv2985
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3342165..3343118)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 2-phospho-L-lactate guanylyltransferase Neighboring gene polyphosphate kinase Neighboring gene DNA-binding protein HU Neighboring gene 3-isopropylmalate dehydratase small subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance. Patil AG, et al. J Biol Chem, 2013 Apr 19. PMID 23463507, Free PMC Article
  2. Identification of Nudix hydrolase family members with an antimutator role in Mycobacterium tuberculosis and Mycobacterium smegmatis. Dos Vultos T, et al. J Bacteriol, 2006 Apr. PMID 16585780, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the concerted action of MtuMutT1 and Rv1700 plays a crucial role in survival of bacteria against oxidative stress.
    Title: Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.
  2. results indicate that MutT1 has an antimutator role; an 8-oxo-guanosine triphosphatase function is suggested
    Title: Identification of Nudix hydrolase family members with an antimutator role in Mycobacterium tuberculosis and Mycobacterium smegmatis.
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General gene information

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Homology

General protein information

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Preferred Names
8-oxo-dGTP diphosphatase
NP_217501.1
  • hydrolase MutT1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3342165..3343118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217501.1 8-oxo-dGTP diphosphatase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217501.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4MLT6
    Conserved Domains (2) summary
    cd07067
    Location:155 → 296
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd03673
    Location:17 → 148
    Ap6A_hydrolase; Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIY3.1

Gene LinkOut

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Molecular Biology Databases
Research Materials