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rpoB DNA-directed RNA polymerase subunit beta [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888164, updated on 31-Aug-2024
Gene symbol
rpoB
Gene description
DNA-directed RNA polymerase subunit beta
Locus tag
Rv0667
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (759807..763325)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene antitoxin VapB8 Neighboring gene ribonuclease VapC8 Neighboring gene membrane protein Neighboring gene DNA-directed RNA polymerase subunit beta' Neighboring gene neutral ceramidase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. [Clinical application of line probe assay (LiPA) for rifampicin (RFP)-resistant gene examination in sputum from tuberculosis patients]. Inagaki T, et al. Kekkaku, 2010 Sep. PMID 20960950
  2. Analysis of the Molecular Evolution of the Mycobacterium Tuberculosis Drug-Resistant Gene rpoB in Asia Using a Bayesian Evolutionary Method. Xu G, et al. Clin Lab, 2015. PMID 26427147
  3. [ANALYSIS OF MUTATION IN CODON 531 rpoB GENE, ASSOCIATED WITH RIFAMPICIN RESISTANCE AMONG SAMPLES OF MYCOBACTERIUM TUBERCULOSIS THAT WAS ISOLATED FROM THE PATIENTS]. Poteĭko PI, et al. Lik Sprava, 2014 Jul-Aug. PMID 26118085
  4. Whole Genome Sequencing Investigation of a Tuberculosis Outbreak in Port-au-Prince, Haiti Caused by a Strain with a "Low-Level" rpoB Mutation L511P - Insights into a Mechanism of Resistance Escalation. Ocheretina O, et al. PLoS One, 2015. PMID 26039194, Free PMC Article
  5. The pattern of rpoB gene mutation of Mycobacterium tuberculosis and predictors of rifampicin resistance detected by GeneXpert MTB/RIF assay in Tanzania. Torokaa PR, et al. PLoS One, 2024. PMID 39186753, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The pattern of rpoB gene mutation of Mycobacterium tuberculosis and predictors of rifampicin resistance detected by GeneXpert MTB/RIF assay in Tanzania.
    Title: The pattern of rpoB gene mutation of Mycobacterium tuberculosis and predictors of rifampicin resistance detected by GeneXpert MTB/RIF assay in Tanzania.
  2. Mycobacterium tuberculosis carrying the rifampicin drug-resistance-conferring rpoB mutation H445Y is associated with suppressed immunity through type I interferons.
    Title: Mycobacterium tuberculosis carrying the rifampicin drug-resistance-conferring rpoB mutation H445Y is associated with suppressed immunity through type I interferons.
  3. The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding.
    Title: The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding.
  4. Detecting Mycobacterium tuberculosis complex and rifampicin resistance via a new rapid multienzyme isothermal point mutation assay.
    Title: Detecting Mycobacterium tuberculosis complex and rifampicin resistance via a new rapid multienzyme isothermal point mutation assay.
  5. Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region.
    Title: Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region.
  6. Determination of potentially novel compensatory mutations in rpoc associated with rifampin resistance and rpob mutations in Mycobacterium tuberculosis Clinical isolates from peru.
    Title: Determination of potentially novel compensatory mutations in rpoc associated with rifampin resistance and rpob mutations in Mycobacterium tuberculosis Clinical isolates from peru.
  7. Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India.
    Title: Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India.
  8. Sequencing analysis found of the 25 mutations found post-pre-rifampicin resistance determining region (RRDR), 14 were only in resistant isolates, and the most frequent was D853N, which was present in 85% of isolates.
    Title: Sequencing of the entire rpob gene and characterization of mutations in isolates of Mycobacterium tuberculosis circulating in an endemic tuberculosis setting.
  9. This study provides valuable information on the diversity of polymorphisms in genes related to multidrug-resistant tuberculosis (including rpoB), as well as the presence of new mutations not previously described; this information should be considered in the implementation of molecular diagnostic tests
    Title: rpoB, katG and inhA mutations in multi-drug resistant strains of Mycobacterium tuberculosis clinical isolates from southeast Mexico.
  10. MALDI-TOF MS methodology is simple, rapid and associated with lower consumable costs than GenoType((R)). The partial rpobeta sequencing methods with BLAST and phylogenetic analysis were not able to identify some RGM unequivocally. Therefore, sequencing of additional regions would be indicated in these cases
    Title: Comparative evaluation of the identification of rapidly growing non-tuberculous mycobacteria by mass spectrometry (MALDI-TOF MS), GenoType Mycobacterium CM/AS assay and partial sequencing of the rpoβ gene with phylogenetic analysis as a reference method.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Homology

Preferred Names
DNA-directed RNA polymerase subunit beta
NP_215181.1
  • transcriptase beta chain (RNA polymerase beta subunit)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    759807..763325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215181.1 DNA-directed RNA polymerase subunit beta [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215181.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A5U052
    Conserved Domains (1) summary
    PRK00405
    Location:28 → 1138
    rpoB; DNA-directed RNA polymerase subunit beta; Reviewed
Nucleotide Protein
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