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mmaA4 hydroxymycolate synthase MmaA4 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888056, updated on 6-Aug-2024

Summary

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Gene symbol
mmaA4
Gene description
hydroxymycolate synthase MmaA4
Locus tag
Rv0642c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (736298..737203, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal protein L11 Neighboring gene 50S ribosomal protein L1 Neighboring gene methoxy mycolic acid synthase MmaA3 Neighboring gene cyclopropane mycolic acid synthase CmaA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis. Alahari A, et al. Mol Microbiol, 2009 Mar. PMID 19183278
  2. Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production. Dao DN, et al. PLoS Pathog, 2008 Jun 6. PMID 18535659, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mmaA4 mutants were highly resistant to thiacetazone and lacked keto-mycolic acids in the cell wall.
    Title: Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis.
  2. Mutants in which mmaA4 (hma) was inactivated stimulated macrophages to produce significantly more IL-12p40 and TNF-alpha than wild-type M. tuberculosis and were attenuated for virulence
    Title: Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
hydroxymycolate synthase MmaA4
NP_215156.1
  • methyl mycolic acid synthase 4 (MMA4) (hydroxy mycolic acid synthase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    736298..737203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215156.1 hydroxymycolate synthase MmaA4 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215156.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A066S9D1, R4M388, R4M5P1
    Conserved Domains (1) summary
    pfam02353
    Location:13 → 290
    CMAS; Mycolic acid cyclopropane synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q79FX8.1

Gene LinkOut

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