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hadC (3R)-hydroxyacyl-ACP dehydratase subunit HadC [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888019, updated on 6-Oct-2023
Gene symbol
hadC
Gene description
(3R)-hydroxyacyl-ACP dehydratase subunit HadC
Locus tag
Rv0637
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Try the new Transcripts and proteins table
Sequence:
NC_000962.3 (732825..733325)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal protein L33 Neighboring gene (3R)-hydroxyacyl-ACP dehydratase subunit HadA Neighboring gene (3R)-hydroxyacyl-ACP dehydratase subunit HadB Neighboring gene tRNA-Trp Neighboring gene preprotein translocase SecE

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis. Slama N, et al. Mol Microbiol, 2016 Feb. PMID 26538472
  2. Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis. Gannoun-Zaki L, et al. Antimicrob Agents Chemother, 2013 Jan. PMID 23114755, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings show that mutation or deletion of hadC affects the biosynthesis of oxygenated mycolic acids, substantially reducing their production level; deletion of hadC leads to a dramatic loss of virulence
    Title: The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis.
  2. Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis.
    Title: Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Homology

Preferred Names
(3R)-hydroxyacyl-ACP dehydratase subunit HadC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    732825..733325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215151.1 (3R)-hydroxyacyl-ACP dehydratase subunit HadC [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215151.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W454
    Conserved Domains (1) summary
    PRK13691
    Location:1 → 166
    PRK13691; (3R)-hydroxyacyl-ACP dehydratase subunit HadC; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WFJ9.1

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