U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nat arylamine N-acetyltransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888005, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
nat
Gene description
arylamine N-acetyltransferase
Locus tag
Rv3566c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
nhoA
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (4007331..4008182, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase FadE31 Neighboring gene acyl-CoA dehydrogenase FadE32 Neighboring gene acyl-CoA dehydrogenase FadE33 Neighboring gene aspartate aminotransferase AspB Neighboring gene hypothetical protein Neighboring gene flavin-dependent monooxygenase reductase subunit HsaB Neighboring gene extradiol dioxygenase Neighboring gene 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. Lack NA, et al. Biochem J, 2009 Mar 1. PMID 19014350
  2. Sequence and structural characterization of tbnat gene in isoniazid-resistant Mycobacterium tuberculosis: identification of new mutations. Coelho MB, et al. Mutat Res, 2011 Jul 1. PMID 21514309
  3. Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis. Sikora AL, et al. Biochemistry, 2008 Oct 7. PMID 18795795, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of tbnat that present non-synonymous mutations indicates that both substitutions are plausible to affect enzyme specificity or acetyl-CoA binding capacity.
    Title: Sequence and structural characterization of tbnat gene in isoniazid-resistant Mycobacterium tuberculosis: identification of new mutations.
  2. As propionyl-CoA is a product of cholesterol catabolism, we propose that NAT could have a role in the utilization of this important cofactor.
    Title: Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.
  3. Steady-state kinetic analysis of TBNAT reveals that the enzyme catalyzes the reaction via a bi-bi ping-pong kinetic mechanism.
    Title: Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
arylamine N-acetyltransferase
YP_177989.1
  • Nat (arylamine acetylase)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4007331..4008182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177989.1 arylamine N-acetyltransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177989.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    V5NFA9
    Conserved Domains (1) summary
    COG2162
    Location:1 → 277
    NhoA; Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport and catabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4BGF_A.1
4BGF_B.1
4BGF_C.1
4BGF_D.1
4BGF_E.1
4BGF_F.1
4BGF_G.1
4BGF_H.1
P9WJI5.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials