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SGPL1 sphingosine-1-phosphate lyase 1 [ Homo sapiens (human) ]

Gene ID: 8879, updated on 5-Sep-2021

Summary

Official Symbol
SGPL1provided by HGNC
Official Full Name
sphingosine-1-phosphate lyase 1provided by HGNC
Primary source
HGNC:HGNC:10817
See related
Ensembl:ENSG00000166224 MIM:603729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPL; S1PL; NPHS14
Expression
Ubiquitous expression in urinary bladder (RPKM 14.9), skin (RPKM 13.8) and 25 other tissues See more
Orthologs
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Genomic context

See SGPL1 in Genome Data Viewer
Location:
10q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (70815920..70881184)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72575704..72640941)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene thymus, brain and testes associated Neighboring gene ribosomal protein S26 pseudogene 40 Neighboring gene pterin-4 alpha-carbinolamine dehydratase 1 Neighboring gene long intergenic non-protein coding RNA 2622

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with sphingosine-1-phosphate lyase 1 (SGPL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13811, KIAA1252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables sphinganine-1-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sphinganine-1-phosphate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sphinganine-1-phosphate aldolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sphinganine-1-phosphate aldolase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables sphinganine-1-phosphate aldolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in Leydig cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in estrogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in luteinization IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in sphingolipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sphingolipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sphingolipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphingolipid catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
sphingosine-1-phosphate lyase 1
Names
SP-lyase 1
SPL 1
hSPL
sphingosine-1-phosphate aldolase
NP_003892.2
XP_005270320.1
XP_006718116.1
XP_011538618.1
XP_011538619.1
XP_011538620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003901.4NP_003892.2  sphingosine-1-phosphate lyase 1

    See identical proteins and their annotated locations for NP_003892.2

    Status: VALIDATED

    Source sequence(s)
    AC073176, BC052991, BP314104
    Consensus CDS
    CCDS31216.1
    UniProtKB/Swiss-Prot
    O95470
    Related
    ENSP00000362298.3, ENST00000373202.8
    Conserved Domains (1) summary
    cd06450
    Location:144507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    70815920..70881184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540316.2XP_011538618.1  sphingosine-1-phosphate lyase 1 isoform X1

    See identical proteins and their annotated locations for XP_011538618.1

    UniProtKB/Swiss-Prot
    O95470
    Conserved Domains (1) summary
    cd06450
    Location:144507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  2. XM_011540318.1XP_011538620.1  sphingosine-1-phosphate lyase 1 isoform X2

    See identical proteins and their annotated locations for XP_011538620.1

    Conserved Domains (1) summary
    cd06450
    Location:64427
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  3. XM_006718053.1XP_006718116.1  sphingosine-1-phosphate lyase 1 isoform X2

    See identical proteins and their annotated locations for XP_006718116.1

    Conserved Domains (1) summary
    cd06450
    Location:64427
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  4. XM_005270263.1XP_005270320.1  sphingosine-1-phosphate lyase 1 isoform X1

    See identical proteins and their annotated locations for XP_005270320.1

    UniProtKB/Swiss-Prot
    O95470
    Conserved Domains (1) summary
    cd06450
    Location:144507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  5. XM_011540317.1XP_011538619.1  sphingosine-1-phosphate lyase 1 isoform X1

    See identical proteins and their annotated locations for XP_011538619.1

    UniProtKB/Swiss-Prot
    O95470
    Conserved Domains (1) summary
    cd06450
    Location:144507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
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