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SGPL1 sphingosine-1-phosphate lyase 1 [ Homo sapiens (human) ]

Gene ID: 8879, updated on 2-Oct-2018

Summary

Official Symbol
SGPL1provided by HGNC
Official Full Name
sphingosine-1-phosphate lyase 1provided by HGNC
Primary source
HGNC:HGNC:10817
See related
Ensembl:ENSG00000166224 MIM:603729; Vega:OTTHUMG00000018421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPL; S1PL; NPHS14
Expression
Ubiquitous expression in urinary bladder (RPKM 14.9), skin (RPKM 13.8) and 25 other tissues See more
Orthologs

Genomic context

See SGPL1 in Genome Data Viewer
Location:
10q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (70815920..70881189)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72575704..72640946)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene thymus, brain and testes associated Neighboring gene ribosomal protein S26 pseudogene 40 Neighboring gene pterin-4 alpha-carbinolamine dehydratase 1 Neighboring gene uncharacterized LOC105378349

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with sphingosine-1-phosphate lyase 1 (SGPL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13811, KIAA1252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphinganine-1-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphinganine-1-phosphate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
sphinganine-1-phosphate aldolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphinganine-1-phosphate aldolase activity NAS
Non-traceable Author Statement
more info
PubMed 
sphinganine-1-phosphate aldolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Leydig cell differentiation IEA
Inferred from Electronic Annotation
more info
 
ameboidal-type cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
estrogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
luteinization IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 
sphingolipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingolipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
sphingolipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingolipid catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
sphingolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
sphingosine-1-phosphate lyase 1
Names
SP-lyase 1
SPL 1
hSPL
sphingosine-1-phosphate aldolase
NP_003892.2
XP_005270320.1
XP_006718116.1
XP_011538618.1
XP_011538619.1
XP_011538620.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003901.3NP_003892.2  sphingosine-1-phosphate lyase 1

    See identical proteins and their annotated locations for NP_003892.2

    Status: VALIDATED

    Source sequence(s)
    AC073176, BC052991, BP314104
    Consensus CDS
    CCDS31216.1
    UniProtKB/Swiss-Prot
    O95470
    Related
    ENSP00000362298.3, OTTHUMP00000019766, ENST00000373202.7, OTTHUMT00000048533
    Conserved Domains (1) summary
    cd06450
    Location:144507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    70815920..70881189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540316.2XP_011538618.1  sphingosine-1-phosphate lyase 1 isoform X1

    See identical proteins and their annotated locations for XP_011538618.1

    UniProtKB/Swiss-Prot
    O95470
    Conserved Domains (1) summary
    cd06450
    Location:144507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  2. XM_011540318.1XP_011538620.1  sphingosine-1-phosphate lyase 1 isoform X2

    See identical proteins and their annotated locations for XP_011538620.1

    Conserved Domains (1) summary
    cd06450
    Location:64427
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  3. XM_006718053.1XP_006718116.1  sphingosine-1-phosphate lyase 1 isoform X2

    See identical proteins and their annotated locations for XP_006718116.1

    Conserved Domains (1) summary
    cd06450
    Location:64427
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  4. XM_005270263.1XP_005270320.1  sphingosine-1-phosphate lyase 1 isoform X1

    See identical proteins and their annotated locations for XP_005270320.1

    UniProtKB/Swiss-Prot
    O95470
    Conserved Domains (1) summary
    cd06450
    Location:144507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  5. XM_011540317.1XP_011538619.1  sphingosine-1-phosphate lyase 1 isoform X1

    See identical proteins and their annotated locations for XP_011538619.1

    UniProtKB/Swiss-Prot
    O95470
    Conserved Domains (1) summary
    cd06450
    Location:144507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
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