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groEL1 chaperonin GroEL [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887877, updated on 6-Oct-2023

Summary

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Gene symbol
groEL1
Gene description
chaperonin GroEL
Locus tag
Rv3417c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
cpn60_1
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Genomic context

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Sequence:
NC_000962.3 (3835272..3836891, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene redox-responsive transcriptional regulator WhiB3 Neighboring gene chaperonin GroES Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene ribosomal-protein-alanine acetyltransferase RimI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Towards understanding the biological function of the unusual chaperonin Cpn60.1 (GroEL1) of Mycobacterium tuberculosis. Sharma A, et al. Tuberculosis (Edinb), 2016 Mar. PMID 26822628
  2. The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts. Winrow VR, et al. Cell Microbiol, 2008 Oct. PMID 18616692
  3. The alr-groEL1 operon in Mycobacterium tuberculosis: an interplay of multiple regulatory elements. Bhat AH, et al. Sci Rep, 2017 Mar 3. PMID 28256563, Free PMC Article
  4. Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages. Hickey TB, et al. Infect Immun, 2009 Aug. PMID 19470749, Free PMC Article
  5. Endocytosis of Mycobacterium tuberculosis heat shock protein 60 is required to induce interleukin-10 production in macrophages. Parveen N, et al. J Biol Chem, 2013 Aug 23. PMID 23846686, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The architecture of alanine racemase (alr)-chaperonin GroEL (groEL1) operon, conservation of the genetic context and a mosaic transcriptional profile displayed under various stress conditions convincingly suggest the involvement of this operon in stress adaptation.
    Title: The alr-groEL1 operon in Mycobacterium tuberculosis: an interplay of multiple regulatory elements.
  2. Suggest an important role of Cpn60.1 (GroEL1) for survival of mycobacterium tuberculosis under low aeration by affecting the expression of genes known for hypoxia response.
    Title: Towards understanding the biological function of the unusual chaperonin Cpn60.1 (GroEL1) of Mycobacterium tuberculosis.
  3. Endocytosis of Mycobacterium tuberculosis heat shock protein 60 is required to induce interleukin-10 production in macrophages.
    Title: Endocytosis of Mycobacterium tuberculosis heat shock protein 60 is required to induce interleukin-10 production in macrophages.
  4. study found that the M. tuberculosis Cpn60.2 molecular chaperone is the major mycobacterial surface ligand that interacts with CD43 to stabilize the interaction between M. tuberculosis and the macrophage
    Title: Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.
  5. These findings suggest that while M. tuberculosis displays both surface-associated Cpn60.2 and DnaK, only Cpn60.2 demonstrates adhesin functionality with regard to macrophage interaction.
    Title: Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages.
  6. these findings reveal that M. tuberculosis Cpn60.1 is a potent and novel inhibitor of osteoclastogenesis both in vitro and in vivo and a potential cure for bone-resorptive diseases like osteoporosis.
    Title: The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts.
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General gene information

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Homology

General protein information

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Preferred Names
chaperonin GroEL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3835272..3836891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217934.1 chaperonin GroEL [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217934.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M2L4
    Conserved Domains (1) summary
    PRK12849
    Location:1 → 529
    groEL; chaperonin GroEL; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPE9.1

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