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ahpE peroxiredoxin [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887871, updated on 11-Dec-2020
Gene symbol
ahpE
Gene description
peroxiredoxin
Locus tag
Rv2238c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2510715..2511176, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene tRNA-Val Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol. Kumar A, et al. Free Radic Biol Med, 2016 Aug. PMID 27417938
  2. Molecular Basis of Hydroperoxide Specificity in Peroxiredoxins: The Case of AhpE from Mycobacterium tuberculosis. Zeida A, et al. Biochemistry, 2015 Dec 15. PMID 26569371
  3. Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Hugo M, et al. Biochemistry, 2009 Oct 13. PMID 19737009
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystallographic structures reveal conformational changes of important residues during the catalytic cycle of MtAhpE.
    Title: Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol.
  2. Molecular Basis of Hydroperoxide Specificity in Peroxiredoxins: The Case of AhpE from Mycobacterium tuberculosis.
    Title: Molecular Basis of Hydroperoxide Specificity in Peroxiredoxins: The Case of AhpE from Mycobacterium tuberculosis.
  3. AhpE is a relevant component in the antioxidant repertoire of M. tuberculosis and could play a role for selected cytotoxic peroxide detoxification, especially peroxynitrite.
    Title: Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics.
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Homology

Preferred Names
peroxiredoxin

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2510715..2511176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216754.1 peroxiredoxin [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216754.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WIE3
    UniProtKB/TrEMBL
    I6YCW8
    Conserved Domains (1) summary
    cd03018
    Location:2 → 150
    PRX_AhpE_like; Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIE3.1

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