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vapB26 antitoxin VapB26 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887739, updated on 6-Oct-2023
Gene symbol
vapB26
Gene description
antitoxin VapB26
Locus tag
Rv0581
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (677710..677925)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ribonuclease VapC26 Neighboring gene lipoprotein LpqN Neighboring gene glycosidase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides. Kang SM, et al. Nucleic Acids Res, 2017 Aug 21. PMID 28575388, Free PMC Article
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that VapC26 toxin contains a pilus retraction protein (PilT) N-terminal (PIN) domain that is essential for ribonuclease activity and that, the VapB26 antitoxin folds into a ribbon-helix-helix DNA-binding motif at the N-terminus.
    Title: Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides.
Submit: New GeneRIF Correction

Homology

Preferred Names
antitoxin VapB26
NP_215095.1
  • part of toxin-antitoxin (TA) operon with Rv0582

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    677710..677925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215095.1 antitoxin VapB26 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215095.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W447
    Conserved Domains (1) summary
    cd21631
    Location:3 → 42
    RHH_CopG_NikR-like; ribbon-helix-helix domains of transcription repressor CopG, nickel responsive transcription factor NikR, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O53778.1

Gene LinkOut

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Molecular Biology Databases
Research Materials