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TB27.3 hypothetical protein [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887732, updated on 6-Jun-2024
Gene symbol
TB27.3
Gene description
hypothetical protein
Locus tag
Rv0577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
cfp32
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Sequence:
NC_000962.3 (671166..671951)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene oxidoreductase Neighboring gene transcriptional regulator Neighboring gene PE-PGRS family protein PE_PGRS7 Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associated with Neutral Red Staining of Virulent Tuberculosis Strains and Homologue of the Streptomyces coelicolor Protein KbpA. Buchko GW, et al. Biochemistry, 2017 Aug 1. PMID 28692281
  2. Mycobacterium tuberculosis Rv0577, a novel TLR2 agonist, induces maturation of dendritic cells and drives Th1 immune response. Byun EH, et al. FASEB J, 2012 Jun. PMID 22415304
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that Rv0577 is composed of four approximate repeats with a betaalphabetabetabeta topology arranged radially in consecutive pairs to form two continuous eight-strand beta-sheets capped on both ends with an alpha-helix. The two beta-sheets intersect in the center at roughly a right angle and form two asymmetric deep "saddles" that may serve to bind ligands such as neutral red and deoxyadenosine.
    Title: Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associated with Neutral Red Staining of Virulent Tuberculosis Strains and Homologue of the Streptomyces coelicolor Protein KbpA.
  2. Rv0577 may regulate innate and adaptive immunity by interacting with TLR2
    Title: Mycobacterium tuberculosis Rv0577, a novel TLR2 agonist, induces maturation of dendritic cells and drives Th1 immune response.
Submit: New GeneRIF Correction

Homology

Preferred Names
hypothetical protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    671166..671951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215091.1 hypothetical protein Rv0577 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215091.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    B6ZBQ7
    Conserved Domains (2) summary
    COG3324
    Location:135 → 259
    COG3324; Predicted enzyme related to lactoylglutathione lyase [General function prediction only]
    cd07247
    Location:12 → 128
    SgaA_N_like; N-terminal domain of Streptomyces griseus SgaA and similar domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIR3.1

Gene LinkOut

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Molecular Biology Databases