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pyrH uridylate kinase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887709, updated on 6-Oct-2023
Gene symbol
pyrH
Gene description
uridylate kinase
Locus tag
Rv2883c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (3192373..3193158, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene phosphatidate cytidylyltransferase Neighboring gene ribosome recycling factor Neighboring gene transcriptional regulator Neighboring gene transposase Neighboring gene resolvase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation. Labesse G, et al. Nucleic Acids Res, 2011 Apr. PMID 21149268, Free PMC Article
  2. UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation. Rostirolla DC, et al. Arch Biochem Biophys, 2011 Jan 15. PMID 21035424
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A key residue involved in the allosteric regulation of uridine monophosphate kinase was identified.
    Title: Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
  2. describe Mycobacterium tuberculosis UMPK (MtUMPK) cloning and expression in Escherichia coli
    Title: UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation.
Submit: New GeneRIF Correction

Homology

Preferred Names
uridylate kinase
NP_217399.1
  • UK (uridine monophosphate kinase) (UMP kinase)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3192373..3193158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217399.1 uridylate kinase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217399.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4MK42
    Conserved Domains (1) summary
    cd04254
    Location:31 → 260
    AAK_UMPK-PyrH-Ec; UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WHK5.1

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