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ruvA Holliday junction ATP-dependent DNA helicase RuvA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887688, updated on 6-Oct-2023
Gene symbol
ruvA
Gene description
Holliday junction ATP-dependent DNA helicase RuvA
Locus tag
Rv2593c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2924230..2924820, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene fatty-acid--CoA ligase FadD9 Neighboring gene PE-PGRS family protein PE_PGRS44 Neighboring gene Holliday junction ATP-dependent DNA helicase RuvB Neighboring gene crossover junction endodeoxyribonuclease RuvC Neighboring gene antitoxin VapB40 Neighboring gene ribonuclease VapC40 Neighboring gene membrane protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability. Prabu JR, et al. Biochim Biophys Acta, 2009 Jul. PMID 19374958
  2. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Prabu JR, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Aug 1. PMID 16880543, Free PMC Article
  3. Functional analysis of DNA replication fork reversal catalyzed by Mycobacterium tuberculosis RuvAB proteins. Khanduja JS, et al. J Biol Chem, 2012 Jan 6. PMID 22094465, Free PMC Article
  4. Mycobacterium tuberculosis RecG protein but not RuvAB or RecA protein is efficient at remodeling the stalled replication forks: implications for multiple mechanisms of replication restart in mycobacteria. Thakur RS, et al. J Biol Chem, 2015 Oct 2. PMID 26276393, Free PMC Article
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RecG protein but not RuvAB or RecA protein is efficient at remodeling the stalled replication forks
    Title: Mycobacterium tuberculosis RecG protein but not RuvAB or RecA protein is efficient at remodeling the stalled replication forks: implications for multiple mechanisms of replication restart in mycobacteria.
  2. The fork reversal reaction catalyzed by MtRuvAB is coupled to ATP hydrolysis, is processive, and culminates in the formation of an extended reverse DNA arm.
    Title: Functional analysis of DNA replication fork reversal catalyzed by Mycobacterium tuberculosis RuvAB proteins.
  3. models emphasize the additional role of the RuvB-binding domain in Holliday junction binding
    Title: Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability.
  4. plasticity in the RuvA molecules has led to insights into the invariant and variable regions providing a framework for understanding regional flexibility in various aspects of RuvA function.
    Title: Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination.
Submit: New GeneRIF Correction

Homology

Preferred Names
Holliday junction ATP-dependent DNA helicase RuvA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2924230..2924820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217109.1 Holliday junction ATP-dependent DNA helicase RuvA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217109.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655JDL5
    Conserved Domains (1) summary
    PRK00116
    Location:1 → 193
    ruvA; Holliday junction branch migration protein RuvA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2H5X_A.1
2H5X_B.1
2H5X_C.1
2H5X_D.1
P9WGW3.1

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