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ptkA protein tyrosine kinase transcriptional regulator PtkA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887597, updated on 6-Oct-2023
Gene symbol
ptkA
Gene description
protein tyrosine kinase transcriptional regulator PtkA
Locus tag
Rv2232
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2506278..2507153)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase Neighboring gene aminotransferase Neighboring gene ribonuclease VapC16 Neighboring gene antitoxin VapB16 Neighboring gene protein-tyrosine-phosphatase Neighboring gene transmembrane protein Neighboring gene cobalamin biosynthesis transmembrane protein CobD Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A. Niesteruk A, et al. FEBS Lett, 2018 Apr. PMID 29494752
  2. Microbial protein-tyrosine kinases. Chao JD, et al. J Biol Chem, 2014 Apr 4. PMID 24554699, Free PMC Article
  3. The domain architecture of PtkA, the first tyrosine kinase from Mycobacterium tuberculosis, differs from the conventional kinase architecture. Niesteruk A, et al. J Biol Chem, 2018 Jul 27. PMID 29884774, Free PMC Article
  4. Protein tyrosine kinase A modulates intracellular survival of mycobacteria through Galectin 3. Jaiswal S, et al. Biochem Biophys Res Commun, 2018 Apr 15. PMID 29545176
  5. Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases. Zhou P, et al. Biochem Biophys Res Commun, 2015 Nov 13. PMID 26417687

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using NMR spectroscopy, this study provides a detailed structural characterization of the PtkA architecture and describes its intra- and intermolecular interactions with MptpA (low-molecular-weight protein tyrosine phosphatase A).
    Title: The domain architecture of PtkA, the first tyrosine kinase from Mycobacterium tuberculosis, differs from the conventional kinase architecture.
  2. results confirm that the N-terminal domain of PtkA exists as an IDD at physiological pH. Furthermore, phosphorylation of IDDPtkA increases the activity of PtkA.
    Title: Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.
  3. Protein tyrosine kinase A modulates intracellular survival of mycobacteria through Galectin 3
    Title: Protein tyrosine kinase A modulates intracellular survival of mycobacteria through Galectin 3.
  4. PknA and its isoforms can phosphorylate PtkA in a dose- and time-dependent manner.
    Title: Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases.
  5. phylogeny, and function of the various prokaryotic protein-tyrosine kinases, focusing on the recently discovered Mycobacterium tuberculosis PtkA and its relationship with other members of this diverse family of proteins
    Title: Microbial protein-tyrosine kinases.
Submit: New GeneRIF Correction

Homology

Preferred Names
protein tyrosine kinase transcriptional regulator PtkA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2506278..2507153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216748.2 protein tyrosine kinase transcriptional regulator PtkA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216748.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M8M6
    Conserved Domains (1) summary
    cd04302
    Location:82 → 286
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPI9.1

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