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ilvC ketol-acid reductoisomerase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887483, updated on 26-Jun-2025
Gene symbol
ilvC
Gene description
ketol-acid reductoisomerase
Locus tag
Rv3001c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (3359585..3360586, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene lipoprotein LppY Neighboring gene transmembrane protein Neighboring gene acetolactate synthase small subunit Neighboring gene acetolactate synthase large subunit IlvB

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery. Lv Y, et al. FEBS J, 2016 Apr. PMID 26876563
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the active site of Ketol-acid reductoisomerase (KARI) is solvent-accessible with the two metal ions separated by 4.7 A.
    Title: Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery.
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Homology

Preferred Names
ketol-acid reductoisomerase
NP_217517.3
  • acetohydroxy-acid isomeroreductase (alpha-keto-beta-hydroxylacil reductoisomerase)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3359585..3360586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217517.3 ketol-acid reductoisomerase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217517.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A1KMZ6, A5U713, L0TE69, O53248, P65149, P9WKJ6, P9WKJ7
    UniProtKB/TrEMBL
    A0A062WII2, R4M9V0
    Conserved Domains (1) summary
    PRK05479
    Location:1 → 326
    PRK05479; ketol-acid reductoisomerase; Provisional
Nucleotide Protein
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