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RRP36 ribosomal RNA processing 36 [ Homo sapiens (human) ]

Gene ID: 88745, updated on 5-Apr-2020

Summary

Official Symbol
RRP36provided by HGNC
Official Full Name
ribosomal RNA processing 36provided by HGNC
Primary source
HGNC:HGNC:21374
See related
Ensembl:ENSG00000124541 MIM:613475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf153; dJ20C7.4
Summary
RRP36 functions at an early stage in the processing of 35S preribosomal RNA into the mature 18S species (Gerus et al., 2010 [PubMed 20038530]).[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in appendix (RPKM 16.4), lymph node (RPKM 15.5) and 25 other tissues See more
Orthologs

Genomic context

See RRP36 in Genome Data Viewer
Location:
6p21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43021602..43029599)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42989385..42997337)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene male-enhanced antigen 1 Neighboring gene protein phosphatase 2 regulatory subunit B'delta Neighboring gene kelch domain containing 3 Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene Neighboring gene cullin 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
cleavage involved in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ribosomal RNA processing protein 36 homolog
Names
RNA processing factor
ribosomal RNA processing 36 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329704.1NP_001316633.1  ribosomal RNA processing protein 36 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC011933, BI828671, CN311647
    UniProtKB/Swiss-Prot
    Q96EU6
  2. NM_033112.4NP_149103.1  ribosomal RNA processing protein 36 homolog isoform 1

    See identical proteins and their annotated locations for NP_149103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC011933, CN311647
    Consensus CDS
    CCDS34453.1
    UniProtKB/Swiss-Prot
    Q96EU6
    Related
    ENSP00000244496.5, ENST00000244496.6
    Conserved Domains (1) summary
    pfam06102
    Location:91245
    DUF947; Domain of unknown function (DUF947)

RNA

  1. NR_138081.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL136304

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43021602..43029599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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