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ARHGEF7 Rho guanine nucleotide exchange factor 7 [ Homo sapiens (human) ]

Gene ID: 8874, updated on 15-Jun-2019

Summary

Official Symbol
ARHGEF7provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 7provided by HGNC
Primary source
HGNC:HGNC:15607
See related
Ensembl:ENSG00000102606 MIM:605477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314
Summary
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in brain (RPKM 14.7), fat (RPKM 11.2) and 25 other tissues See more
Orthologs

Genomic context

See ARHGEF7 in Genome Data Viewer
Location:
13q34
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (111114619..111305734)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111767624..111958081)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370364 Neighboring gene long intergenic non-protein coding RNA 431 Neighboring gene long intergenic non-protein coding RNA 368 Neighboring gene ARHGEF7 antisense RNA 2 Neighboring gene uncharacterized LOC101060553 Neighboring gene ARHGEF7 antisense RNA 1 Neighboring gene spalt like transcription factor 4 pseudogene 4 Neighboring gene uncharacterized LOC105370365 Neighboring gene testis expressed 29 Neighboring gene uncharacterized LOC107984618

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association meta-analysis for total serum bilirubin levels.
NHGRI GWA Catalog
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
NHGRI GWA Catalog
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
NHGRI GWA Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef In the presence of Nef, lipid raft Cdc42 is activated and forms a ternary complex between the c-Cbl-interacting protein p85Cool-1/betaPix and c-Cbl, displacing UbcH7 from rafts PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0142, KIAA0412, DKFZp761K1021, DKFZp686C12170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
PubMed 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
focal adhesion assembly HDA PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity HMP PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of fibroblast migration HDA PubMed 
positive regulation of lamellipodium morphogenesis HMP PubMed 
positive regulation of substrate adhesion-dependent cell spreading HMP PubMed 
regulation of GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 7
Names
PAK-interacting exchange factor beta
Rho guanine nucleotide exchange factor (GEF) 7
SH3 domain-containing proline-rich protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113511.2NP_001106983.1  rho guanine nucleotide exchange factor 7 isoform c

    See identical proteins and their annotated locations for NP_001106983.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform c.
    Source sequence(s)
    AB177848, AK093326, AL353704, BC060776, BM677392, DB180957
    Consensus CDS
    CCDS45068.1
    UniProtKB/Swiss-Prot
    Q14155
    UniProtKB/TrEMBL
    Q5W9H1
    Related
    ENSP00000364893.2, ENST00000375741.6
    Conserved Domains (7) summary
    cd12061
    Location:188241
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:272449
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:480578
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:634732
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:138184
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cl00030
    Location:21128
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl26464
    Location:583664
    Atrophin-1; Atrophin-1 family
  2. NM_001113512.2NP_001106984.1  rho guanine nucleotide exchange factor 7 isoform d

    See identical proteins and their annotated locations for NP_001106984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 3. The resulting protein (isoform d) is shorter than isoform c.
    Source sequence(s)
    AB177848, AK093326, AL353704, BC033905, BC060776, BM677392, DB180957
    Consensus CDS
    CCDS45069.1
    UniProtKB/Swiss-Prot
    Q14155
    UniProtKB/TrEMBL
    Q5W9H1
    Related
    ENSP00000364891.2, ENST00000375739.6
    Conserved Domains (7) summary
    cd12061
    Location:138191
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:2175
    CH; Calponin homology domain
    cd00160
    Location:222399
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:430528
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:448528
    PH; PH domain
    pfam16614
    Location:584682
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:88134
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  3. NM_001113513.2NP_001106985.1  rho guanine nucleotide exchange factor 7 isoform a

    See identical proteins and their annotated locations for NP_001106985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AL390754, BC050521, CF121796, CF144155, D63476, DA216264
    Consensus CDS
    CCDS9521.1
    UniProtKB/Swiss-Prot
    Q14155
    UniProtKB/TrEMBL
    A0A024RDY9
    Related
    ENSP00000397068.2, ENST00000426073.6
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  4. NM_001320851.2NP_001307780.1  rho guanine nucleotide exchange factor 7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AB177849, AL390754, BC050521, CF121796, CF144155, D63476, DA404477
    Consensus CDS
    CCDS9521.1
    UniProtKB/Swiss-Prot
    Q14155
    UniProtKB/TrEMBL
    A0A024RDY9
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  5. NM_001320852.1NP_001307781.1  rho guanine nucleotide exchange factor 7 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (e) lacks a portion of the N-terminus and has a longer, distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Conserved Domains (8) summary
    cd12061
    Location:167220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477557
    PH; PH domain
    pfam16523
    Location:714800
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:613711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  6. NM_001320853.2NP_001307782.1  rho guanine nucleotide exchange factor 7 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (f) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AK300272, BC050521, CF121796, CF144155
    UniProtKB/Swiss-Prot
    Q14155
    UniProtKB/TrEMBL
    B7Z6G2
    Conserved Domains (7) summary
    cd12061
    Location:85138
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:169346
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:377475
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:395475
    PH; PH domain
    pfam16523
    Location:632718
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:531629
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:3581
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  7. NM_001320854.2NP_001307783.1  rho guanine nucleotide exchange factor 7 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (g) has a distinct, shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AK093326, AK295472, AK308897, BC060776, BM677392, DB180957
    Consensus CDS
    CCDS81781.1
    UniProtKB/Swiss-Prot
    Q14155
    UniProtKB/TrEMBL
    B7Z344, E9PDQ5
    Related
    ENSP00000417596.1, ENST00000478679.5
    Conserved Domains (4) summary
    cd00160
    Location:16193
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:224322
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:242322
    PH; PH domain
    pfam16614
    Location:378476
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
  8. NM_001330597.2NP_001317526.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. It initiates translation at a downstream start codon. The resulting protein (isoform h) has a shorter N-terminus than isoform c. Variants 10, 11, and 22-26 all encode the same isoform (h).
    Source sequence(s)
    AB075521, AL139086, AL390754, AW872844, BC060776, D63476, DA404477
    Consensus CDS
    CCDS86362.1
    UniProtKB/Swiss-Prot
    Q14155
    Conserved Domains (5) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  9. NM_001330598.2NP_001317527.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. It initiates translation at a downstream start codon. The resulting protein (isoform h) has a shorter N-terminus than isoform c. Variants 10, 11, and 22-26 all encode the same isoform (h).
    Source sequence(s)
    AB075521, AB177849, AL139086, AL390754, AW872844, BC060776, D63476, DA404477
    Consensus CDS
    CCDS86362.1
    UniProtKB/Swiss-Prot
    Q14155
    Conserved Domains (5) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  10. NM_001354046.1NP_001340975.1  rho guanine nucleotide exchange factor 7 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) encodes the longest isoform (i).
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86360.1
    Related
    ENSP00000495631.1, ENST00000646102.1
    Conserved Domains (8) summary
    cd12061
    Location:167220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:773859
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:613711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cl26464
    Location:562643
    Atrophin-1; Atrophin-1 family
  11. NM_001354047.1NP_001340976.1  rho guanine nucleotide exchange factor 7 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL139086, AL353704, AL390754
    Conserved Domains (6) summary
    cd12061
    Location:95148
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:2196
    CH; Calponin homology domain
    cd00160
    Location:179356
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:387485
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:541639
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:490571
    Atrophin-1; Atrophin-1 family
  12. NM_001354048.1NP_001340977.1  rho guanine nucleotide exchange factor 7 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 15-17, encodes isoform k.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86361.1
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:616702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  13. NM_001354049.2NP_001340978.1  rho guanine nucleotide exchange factor 7 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 14, 16, and 17, encodes isoform k.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86361.1
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:616702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  14. NM_001354050.2NP_001340979.1  rho guanine nucleotide exchange factor 7 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 14, 15, and 17, encodes isoform k.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86361.1
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:616702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  15. NM_001354051.2NP_001340980.1  rho guanine nucleotide exchange factor 7 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 14-16, encodes isoform k.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86361.1
    Related
    ENSP00000218789.5, ENST00000218789.9
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:616702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  16. NM_001354052.2NP_001340981.1  rho guanine nucleotide exchange factor 7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 1, 5, 6, and 19, encodes isoform a.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS9521.1
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  17. NM_001354053.2NP_001340982.1  rho guanine nucleotide exchange factor 7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 1, 5, 6, and 18, encodes isoform a.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS9521.1
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  18. NM_001354054.2NP_001340983.1  rho guanine nucleotide exchange factor 7 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL139086, AL353704, AL390754
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407490
    Atrophin-1; Atrophin-1 family
  19. NM_001354055.2NP_001340984.1  rho guanine nucleotide exchange factor 7 isoform m

    Status: REVIEWED

    Source sequence(s)
    AL139086
    Conserved Domains (5) summary
    cd00160
    Location:16193
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:224322
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:538624
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:378476
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:327408
    Atrophin-1; Atrophin-1 family
  20. NM_001354056.1NP_001340985.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 10, 11, and 23-26, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    Conserved Domains (5) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  21. NM_001354057.2NP_001340986.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 10, 11, 22, and 24-26, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    Conserved Domains (5) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  22. NM_001354058.2NP_001340987.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 10, 11, 22, 23, 25, and 26, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    Conserved Domains (5) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  23. NM_001354059.2NP_001340988.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 10, 11, 22-24, and 26, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    Conserved Domains (5) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  24. NM_001354060.2NP_001340989.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 10, 11, and 22-25, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    Related
    ENSP00000364875.1, ENST00000375723.5
    Conserved Domains (5) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  25. NM_001354061.2NP_001340990.1  rho guanine nucleotide exchange factor 7 isoform n

    Status: REVIEWED

    Source sequence(s)
    AL139086
    Conserved Domains (4) summary
    cd00160
    Location:20147
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:178276
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:332430
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:283366
    Atrophin-1; Atrophin-1 family
  26. NM_003899.5NP_003890.1  rho guanine nucleotide exchange factor 7 isoform a

    See identical proteins and their annotated locations for NP_003890.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS9521.1
    UniProtKB/Swiss-Prot
    Q14155
    UniProtKB/TrEMBL
    A0A024RDY9
    Related
    ENSP00000364888.4, ENST00000375736.8
    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405486
    Atrophin-1; Atrophin-1 family
  27. NM_145735.3NP_663788.1  rho guanine nucleotide exchange factor 7 isoform b

    See identical proteins and their annotated locations for NP_663788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 3. The resulting protein (isoform b) is shorter than isoform c.
    Source sequence(s)
    AB177848, AK093326, AL353704, AL834228, BC060776, BM677392, DB180957
    Consensus CDS
    CCDS32009.1
    UniProtKB/Swiss-Prot
    Q14155
    UniProtKB/TrEMBL
    Q5W9H1
    Related
    ENSP00000325994.5, ENST00000317133.9
    Conserved Domains (7) summary
    cd12061
    Location:167220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477557
    PH; PH domain
    pfam16614
    Location:613711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    111114619..111305734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020815.1XP_016876304.1  rho guanine nucleotide exchange factor 7 isoform X3

  2. XM_006719956.3XP_006720019.1  rho guanine nucleotide exchange factor 7 isoform X1

    Conserved Domains (8) summary
    cd12061
    Location:167220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477557
    PH; PH domain
    pfam16523
    Location:726812
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:613723
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  3. XM_017020814.1XP_016876303.1  rho guanine nucleotide exchange factor 7 isoform X2

  4. XM_011521133.2XP_011519435.1  rho guanine nucleotide exchange factor 7 isoform X7

    Conserved Domains (5) summary
    cd12061
    Location:167220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16615
    Location:117163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cl17171
    Location:459503
    PH-like; Pleckstrin homology-like domain
  5. XM_017020822.1XP_016876311.1  rho guanine nucleotide exchange factor 7 isoform X5

    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407490
    Atrophin-1; Atrophin-1 family
  6. XM_024449428.1XP_024305196.1  rho guanine nucleotide exchange factor 7 isoform X5

    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407490
    Atrophin-1; Atrophin-1 family
  7. XM_017020821.2XP_016876310.1  rho guanine nucleotide exchange factor 7 isoform X5

    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407490
    Atrophin-1; Atrophin-1 family
  8. XM_017020823.2XP_016876312.1  rho guanine nucleotide exchange factor 7 isoform X5

    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407490
    Atrophin-1; Atrophin-1 family
  9. XM_017020820.1XP_016876309.1  rho guanine nucleotide exchange factor 7 isoform X5

    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407490
    Atrophin-1; Atrophin-1 family
  10. XM_017020819.1XP_016876308.1  rho guanine nucleotide exchange factor 7 isoform X5

    Conserved Domains (6) summary
    cd12061
    Location:1063
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407490
    Atrophin-1; Atrophin-1 family
  11. XM_017020816.1XP_016876305.1  rho guanine nucleotide exchange factor 7 isoform X4

  12. XM_017020828.1XP_016876317.1  rho guanine nucleotide exchange factor 7 isoform X6

  13. XM_017020829.2XP_016876318.1  rho guanine nucleotide exchange factor 7 isoform X8

    Conserved Domains (4) summary
    cd00160
    Location:20147
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:178276
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:332430
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:283366
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_002957481.1 RNA Sequence

  2. XR_001749712.1 RNA Sequence

    Related
    ENST00000466143.5
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