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vapB20 antitoxin VapB20 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887353, updated on 6-Oct-2023
Gene symbol
vapB20
Gene description
antitoxin VapB20
Locus tag
Rv2550c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2870119..2870364, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene antitoxin VapB19 Neighboring gene ribonuclease VapC19 Neighboring gene hypothetical protein Neighboring gene ribonuclease VapC20 Neighboring gene hypothetical protein Neighboring gene shikimate 5-dehydrogenase Neighboring gene membrane protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly. Deep A, et al. FEBS J, 2017 Dec. PMID 28986943
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that VapB20 exists as a homodimer in solution and ssociates with VapC20 dimers to form heterotetramers and heterooctamers in a concentration-dependent manner.
    Title: Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly.
Submit: New GeneRIF Correction

Homology

Preferred Names
antitoxin VapB20
NP_217066.1
  • part of toxin-antitoxin (TA) operon with Rv2549c

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2870119..2870364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217066.1 antitoxin VapB20 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217066.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WJ45
    UniProtKB/TrEMBL
    A0A0H3LIZ3
    Conserved Domains (1) summary
    cd21631
    Location:10 → 51
    RHH_CopG_NikR-like; ribbon-helix-helix domains of transcription repressor CopG, nickel responsive transcription factor NikR, and similar proteins
Nucleotide Protein
Heading Accession and Version

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