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ilvB1 acetolactate synthase large subunit IlvB [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887286, updated on 11-Dec-2020
Gene symbol
ilvB1
Gene description
acetolactate synthase large subunit IlvB
Locus tag
Rv3003c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
ilvB
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Sequence:
NC_000962.3 (3361130..3362986, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene ketol-acid reductoisomerase Neighboring gene acetolactate synthase small subunit Neighboring gene low molecular weight protein antigen 6 Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase. Baig IA, et al. Enzyme Microb Technol, 2014 May 10. PMID 24731825
  2. Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase. Baig IA, et al. Enzyme Microb Technol, 2013 Sep 10. PMID 23931689
  3. Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice. Awasthy D, et al. Microbiology (Reading), 2009 Sep. PMID 19542000
  4. The Role of a FAD Cofactor in the Regulation of Acetohydroxyacid Synthase by Redox Signaling Molecules. Lonhienne T, et al. J Biol Chem, 2017 Mar 24. PMID 28159840, Free PMC Article
  5. Biochemical and transcription analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis identifies these enzymes as potential targets for drug development. Singh V, et al. Microbiology (Reading), 2011 Jan. PMID 20884690

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using various soluble quinone derivatives (e.g. ubiquinones), this study reveals a new path of down-regulation of acetolactate synthase activity involving inhibition by oxidized redox-signaling molecules.
    Title: The Role of a FAD Cofactor in the Regulation of Acetohydroxyacid Synthase by Redox Signaling Molecules.
  2. Conserved His84 and Gln86 residues lie in the catalytic dimer interface. Mutation of Gln86 to Trp abolished complete activity. These residues maintain the Glu85 side chain in the required geometry with N1' atom of ThDP during catalysis.
    Title: Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase.
  3. P126V and P126T variants showed a significantly decreased preference toward pyruvate and ThDP as substrate and cofactor respectively, whereas the P126A showed similar kinetics to that of wild-type.
    Title: Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase.
  4. The role of ilvB1 in persistence is known, but the upregulation of ilvB2 and ilvG in extended stationary phase suggests the relevance of acetohydroxyacid synthase enzymes in the metabolism and survival of Mycobacterium tuberculosis.
    Title: Biochemical and transcription analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis identifies these enzymes as potential targets for drug development.
  5. IlvB is the major acetohydroxyacid synthase required for branched-chain amino acid biosynthesis.
    Title: Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice.
Submit: New GeneRIF Correction

Homology

Preferred Names
acetolactate synthase large subunit IlvB
YP_177917.1
  • acetohydroxy-acid synthase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3361130..3362986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177917.1 acetolactate synthase large subunit IlvB [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177917.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WG41
    UniProtKB/TrEMBL
    I6YEX6
    Conserved Domains (1) summary
    PRK07789
    Location:8 → 618
    PRK07789; acetolactate synthase 1 catalytic subunit; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WG41.1

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