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kasA 3-oxoacyl-ACP synthase 1 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887269, updated on 6-Oct-2023
Gene symbol
kasA
Gene description
3-oxoacyl-ACP synthase 1
Locus tag
Rv2245
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2518115..2519365)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene malonyl CoA-acyl carrier protein transacylase Neighboring gene ncRNA Neighboring gene meromycolate extension acyl carrier protein Neighboring gene 3-oxoacyl-ACP synthase 2 Neighboring gene acetyl-/propionyl-CoA carboxylase subunit beta

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The protonation state of catalytic residues in the resting state of KasA revisited: detailed mechanism for the activation of KasA by its own substrate. Lee W, et al. Biochemistry, 2014 Feb 11. PMID 24479625
  2. Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis. Schiebel J, et al. J Biol Chem, 2013 Nov 22. PMID 24108128, Free PMC Article
  3. Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design. Lee W, et al. Biochemistry, 2011 Jun 28. PMID 21615093, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. devised a detailed model about the KasA activation mechanism. A conformational change of Phe404 possibly triggered by the substrate is central for the activation because it switches KasA to the sufficiently reactive zwitterionic state.
    Title: The protonation state of catalytic residues in the resting state of KasA revisited: detailed mechanism for the activation of KasA by its own substrate.
  2. Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis.
    Title: Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis.
  3. Since KasA is essential for the survival of the pathogen, it can serve as a new drug target for treatment of tuberculosis, via use of its cell wall component's active site by means of structural motifs and relative energies.
    Title: Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.
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Homology

Preferred Names
3-oxoacyl-ACP synthase 1
NP_216761.1
  • beta-ketoacyl-ACP synthase (KAS I); belongs to the fas-II system, which utilizes primarily palmitoyl-ACP rather than short-chain acyl-ACP primers.

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2518115..2519365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216761.1 3-oxoacyl-ACP synthase 1 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216761.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M3W9, V5NQS3
    Conserved Domains (1) summary
    cl09938
    Location:1 → 416
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQD9.1

Gene LinkOut

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Molecular Biology Databases