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dnaE2 error-prone DNA polymerase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887259, updated on 26-Jun-2025
Gene symbol
dnaE2
Gene description
error-prone DNA polymerase
Locus tag
Rv3370c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (3781501..3784740, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene PE-PGRS family protein PE_PGRS51 Neighboring gene oxidoreductase Neighboring gene hypothetical protein Neighboring gene diacyglycerol O-acyltransferase Neighboring gene trehalose 6-phosphate phosphatase

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis. Warner DF, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615954, Free PMC Article
  2. Specific mutations in the Mycobacterium tuberculosis rpoB gene are associated with increased dnaE2 expression. Bergval IL, et al. FEMS Microbiol Lett, 2007 Oct. PMID 17868360
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rv3395c (designated imuA') and Rv3394c (imuB) are individually essential for induced mutagenesis and damage tolerance.
    Title: Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis.
  2. The presence of specific mutations in rpoB is not only associated with impaired fitness but also results in a detectable, moderate yet persistent increase in the expression of dnaE2 but not recA.
    Title: Specific mutations in the Mycobacterium tuberculosis rpoB gene are associated with increased dnaE2 expression.
Submit: New GeneRIF Correction

Homology

Preferred Names
error-prone DNA polymerase
NP_217887.3
  • DnaE2 (DNA nucleotidyltransferase)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3781501..3784740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217887.3 error-prone DNA polymerase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217887.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3MEP2, A0AA44LQR8, A0AB74LKN3, A0ABD7H8I9
    Conserved Domains (1) summary
    PRK05672
    Location:42 → 1079
    dnaE2; error-prone DNA polymerase; Validated
Nucleotide Protein
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