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regX3 two component sensory transduction protein RegX [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887195, updated on 9-Aug-2024
Gene symbol
regX3
Gene description
two component sensory transduction protein RegX
Locus tag
Rv0491
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (580809..581492)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Neighboring gene two component sensor histidine kinase SenX3 Neighboring gene GMC-type oxidoreductase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene HTH-type transcriptional regulator

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A systems approach to decipher a role of transcription factor RegX3 in the adaptation of Mycobacterium tuberculosis to hypoxic stress. Mahatha AC, et al. Microbiology (Reading), 2022 Aug. PMID 35980355
  2. RegX3-dependent transcriptional activation of kdpDE and repression of rv0500A are linked to potassium homeostasis in Mycobacterium tuberculosis. Bagchi S, et al. FEBS J, 2024 May. PMID 38414198
  3. Conformational Dynamics of Response Regulator RegX3 from Mycobacterium tuberculosis. Ahmad A, et al. PLoS One, 2015. PMID 26201027, Free PMC Article
  4. The structure of a full-length response regulator from Mycobacterium tuberculosis in a stabilized three-dimensional domain-swapped, activated state. King-Scott J, et al. J Biol Chem, 2007 Dec 28. PMID 17942407
  5. Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E. Sanyal S, et al. Microbiology (Reading), 2013 Oct. PMID 23946493

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RegX3-dependent transcriptional activation of kdpDE and repression of rv0500A are linked to potassium homeostasis in Mycobacterium tuberculosis.
    Title: RegX3-dependent transcriptional activation of kdpDE and repression of rv0500A are linked to potassium homeostasis in Mycobacterium tuberculosis.
  2. A systems approach to decipher a role of transcription factor RegX3 in the adaptation of Mycobacterium tuberculosis to hypoxic stress.
    Title: A systems approach to decipher a role of transcription factor RegX3 in the adaptation of Mycobacterium tuberculosis to hypoxic stress.
  3. PstA1,SenX3 and RegX3 signal transduction system is a novel regulator of membrane vesicle biogenesis.
    Title: Mycobacterium tuberculosis Pst/SenX3-RegX3 Regulates Membrane Vesicle Production Independently of ESX-5 Activity.
  4. findings demonstrate that a phosphate-sensing signal transduction system, comprising the Pst phosphate transporter, the two-component system SenX3-RegX3, and functionally redundant PhoY proteins that mediate signaling between Pst and SenX3-RegX3, influences persister formation.
    Title: Mycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing.
  5. Conformational Dynamics of Response Regulator RegX3 from Mycobacterium tuberculosis.
    Title: Conformational Dynamics of Response Regulator RegX3 from Mycobacterium tuberculosis.
  6. Authors describe the regulatory architecture of a signal transduction system involving the two-component system SenX3-RegX3, the extracytoplasmic function sigma factor sigma E and the poly P-synthesizing enzyme polyphosphate kinase 1.
    Title: Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E.
  7. RegX3 exists as both a monomer and a dimer in a concentration-dependent equilibrium; The dimer in solution differs from the active form and is similar to the inactive full-length response regulator PhoB
    Title: The structure of a full-length response regulator from Mycobacterium tuberculosis in a stabilized three-dimensional domain-swapped, activated state.
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Homology

Preferred Names
two component sensory transduction protein RegX
NP_215005.1
  • response regulator protein (sensory transduction protein)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    580809..581492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215005.1 two component sensory transduction protein RegX [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215005.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3L5Q4
    Conserved Domains (1) summary
    COG0745
    Location:4 → 226
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WGL9.1

Gene LinkOut

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