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vapC20 ribonuclease VapC20 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887193, updated on 6-Oct-2023

Summary

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Gene symbol
vapC20
Gene description
ribonuclease VapC20
Locus tag
Rv2549c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2869727..2870122, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene antitoxin VapB19 Neighboring gene ribonuclease VapC19 Neighboring gene hypothetical protein Neighboring gene antitoxin VapB20 Neighboring gene hypothetical protein Neighboring gene shikimate 5-dehydrogenase Neighboring gene membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly. Deep A, et al. FEBS J, 2017 Dec. PMID 28986943
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that VapB20 exists as a homodimer in solution and ssociates with VapC20 dimers to form heterotetramers and heterooctamers in a concentration-dependent manner.
    Title: Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly.
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General gene information

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Homology

General protein information

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Preferred Names
ribonuclease VapC20
NP_217065.1
  • toxin, part of toxin-antitoxin (TA) operon with Rv2550c,contains PIN domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2869727..2870122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217065.1 ribonuclease VapC20 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217065.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W9X0
    Conserved Domains (1) summary
    cd18680
    Location:3 → 128
    PIN_MtVapC20-like; VapC-like PIN domain of Mycobacterium tuberculosis VapC20 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P95004.1

Gene LinkOut

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Molecular Biology Databases