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senX3 two component sensor histidine kinase SenX3 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887185, updated on 6-Oct-2023
Gene symbol
senX3
Gene description
two component sensor histidine kinase SenX3
Locus tag
Rv0490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (579349..580581)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene amino acid transporter Neighboring gene 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Neighboring gene two component sensory transduction protein RegX Neighboring gene GMC-type oxidoreductase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Virulence factor SenX3 is the oxygen-controlled replication switch of Mycobacterium tuberculosis. Singh N, et al. Antioxid Redox Signal, 2015 Mar 1. PMID 25333974, Free PMC Article
  2. Mycobacterium tuberculosis Pst/SenX3-RegX3 Regulates Membrane Vesicle Production Independently of ESX-5 Activity. White DW, et al. mBio, 2018 Jun 12. PMID 29895636, Free PMC Article
  3. Mycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing. Namugenyi SB, et al. mBio, 2017 Jul 11. PMID 28698272, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PstA1,SenX3 and RegX3 signal transduction system is a novel regulator of membrane vesicle biogenesis.
    Title: Mycobacterium tuberculosis Pst/SenX3-RegX3 Regulates Membrane Vesicle Production Independently of ESX-5 Activity.
  2. findings demonstrate that a phosphate-sensing signal transduction system, comprising the Pst phosphate transporter, the two-component system SenX3-RegX3, and functionally redundant PhoY proteins that mediate signaling between Pst and SenX3-RegX3, influences persister formation.
    Title: Mycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing.
  3. SenX3 mutant of M. tuberculosis is capable of nonreplicating state in response to hypoxic stress, but its regrowth on the restoration of ambient oxygen levels is significantly attenuated compared with the wild-type and the complemented mutant strains.
    Title: Virulence factor SenX3 is the oxygen-controlled replication switch of Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Homology

Preferred Names
two component sensor histidine kinase SenX3

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    579349..580581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215004.1 two component sensor histidine kinase SenX3 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215004.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M3Y1
    Conserved Domains (1) summary
    TIGR02966
    Location:136 → 373
    phoR_proteo; phosphate regulon sensor kinase PhoR
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WGK5.1

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